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Designing Efficient Enzymes: Eight Predicted Mutations Convert a Hydroxynitrile Lyase into an Efficient Esterase.
Casadevall G, Pierce C, Guan B, Iglesias-Fernandez J, Lim HY, Greenberg LR, Walsh ME, Shi K, Gordon W, Aihara H, Evans RL 3rd, Kazlauskas R, Osuna S. Casadevall G, et al. Among authors: iglesias fernandez j. bioRxiv [Preprint]. 2023 Aug 24:2023.08.23.554512. doi: 10.1101/2023.08.23.554512. bioRxiv. 2023. PMID: 37662272 Free PMC article. Preprint.
Controlled sulfur-based engineering confers mouldability to phosphorothioate antisense oligonucleotides.
Genna V, Iglesias-Fernández J, Reyes-Fraile L, Villegas N, Guckian K, Seth P, Wan B, Cabrero C, Terrazas M, Brun-Heath I, González C, Sciabola S, Villalobos A, Orozco M. Genna V, et al. Among authors: iglesias fernandez j. Nucleic Acids Res. 2023 Jun 9;51(10):4713-4725. doi: 10.1093/nar/gkad309. Nucleic Acids Res. 2023. PMID: 37099382 Free PMC article.
Preclinical evaluation of a COVID-19 vaccine candidate based on a recombinant RBD fusion heterodimer of SARS-CoV-2.
Barreiro A, Prenafeta A, Bech-Sabat G, Roca M, Perozo Mur E, March R, González-González L, Madrenas L, Corominas J, Fernández A, Moros A, Cañete M, Molas M, Pentinat-Pelegrin T, Panosa C, Moreno A, Puigvert Molas E, Pol Vilarrassa E, Palmada J, Garriga C, Prat Cabañas T, Iglesias-Fernández J, Vergara-Alert J, Lorca-Oró C, Roca N, Fernández-Bastit L, Rodon J, Pérez M, Segalés J, Pradenas E, Marfil S, Trinité B, Ortiz R, Clotet B, Blanco J, Díaz Pedroza J, Ampudia Carrasco R, Rosales Salgado Y, Loubat-Casanovas J, Capdevila Larripa S, Prado JG, Barretina J, Sisteré-Oró M, Cebollada Rica P, Meyerhans A, Ferrer L. Barreiro A, et al. Among authors: iglesias fernandez j. iScience. 2023 Mar 17;26(3):106126. doi: 10.1016/j.isci.2023.106126. Epub 2023 Feb 2. iScience. 2023. PMID: 36748086 Free PMC article.
MEP pathway products allosterically promote monomerization of deoxy-D-xylulose-5-phosphate synthase to feedback-regulate their supply.
Di X, Ortega-Alarcon D, Kakumanu R, Iglesias-Fernandez J, Diaz L, Baidoo EEK, Velazquez-Campoy A, Rodríguez-Concepción M, Perez-Gil J. Di X, et al. Among authors: iglesias fernandez j. Plant Commun. 2023 May 8;4(3):100512. doi: 10.1016/j.xplc.2022.100512. Epub 2022 Dec 26. Plant Commun. 2023. PMID: 36575800 Free PMC article.
Enzyme Conformation Influences the Performance of Lipase-powered Nanomotors.
Wang L, Marciello M, Estévez-Gay M, Soto Rodriguez PED, Luengo Morato Y, Iglesias-Fernández J, Huang X, Osuna S, Filice M, Sánchez S. Wang L, et al. Among authors: iglesias fernandez j. Angew Chem Int Ed Engl. 2020 Nov 16;59(47):21080-21087. doi: 10.1002/anie.202008339. Epub 2020 Sep 16. Angew Chem Int Ed Engl. 2020. PMID: 32755070
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