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CPEB alteration and aberrant transcriptome-polyadenylation lead to a treatable SLC19A3 deficiency in Huntington's disease.
Picó S, Parras A, Santos-Galindo M, Pose-Utrilla J, Castro M, Fraga E, Hernández IH, Elorza A, Anta H, Wang N, Martí-Sánchez L, Belloc E, Garcia-Esparcia P, Garrido JJ, Ferrer I, Macías-García D, Mir P, Artuch R, Pérez B, Hernández F, Navarro P, López-Sendón JL, Iglesias T, Yang XW, Méndez R, Lucas JJ. Picó S, et al. Among authors: iglesias t. Sci Transl Med. 2021 Sep 29;13(613):eabe7104. doi: 10.1126/scitranslmed.abe7104. Epub 2021 Sep 29. Sci Transl Med. 2021. PMID: 34586830 Free article.
Kidins220 accumulates with tau in human Alzheimer's disease and related models: modulation of its calpain-processing by GSK3β/PP1 imbalance.
López-Menéndez C, Gamir-Morralla A, Jurado-Arjona J, Higuero AM, Campanero MR, Ferrer I, Hernández F, Ávila J, Díaz-Guerra M, Iglesias T. López-Menéndez C, et al. Among authors: iglesias t. Hum Mol Genet. 2013 Feb 1;22(3):466-82. doi: 10.1093/hmg/dds446. Epub 2012 Oct 31. Hum Mol Genet. 2013. PMID: 23118350
Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1.
Pose-Utrilla J, García-Guerra L, Del Puerto A, Martín A, Jurado-Arjona J, De León-Reyes NS, Gamir-Morralla A, Sebastián-Serrano Á, García-Gallo M, Kremer L, Fielitz J, Ireson C, Pérez-Álvarez MJ, Ferrer I, Hernández F, Ávila J, Lasa M, Campanero MR, Iglesias T. Pose-Utrilla J, et al. Among authors: iglesias t. Nat Commun. 2017 Dec 22;8(1):2275. doi: 10.1038/s41467-017-02322-5. Nat Commun. 2017. PMID: 29273751 Free PMC article.
Author Correction: Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1.
Pose-Utrilla J, García-Guerra L, Del Puerto A, Martín A, Jurado-Arjona J, De León-Reyes NS, Gamir-Morralla A, Sebastián-Serrano Á, García-Gallo M, Kremer L, Fielitz J, Ireson C, Pérez-Álvarez MJ, Ferrer I, Hernández F, Ávila J, Lasa M, Campanero MR, Iglesias T. Pose-Utrilla J, et al. Among authors: iglesias t. Nat Commun. 2018 Jan 30;9(1):473. doi: 10.1038/s41467-018-03022-4. Nat Commun. 2018. PMID: 29382840 Free PMC article.
Differential regulation of Kidins220 isoforms in Huntington's disease.
Sebastián-Serrano Á, Simón-García A, Belmonte-Alfaro A, Pose-Utrilla J, Santos-Galindo M, Del Puerto A, García-Guerra L, Hernández IH, Schiavo G, Campanero MR, Lucas JJ, Iglesias T. Sebastián-Serrano Á, et al. Among authors: iglesias t. Brain Pathol. 2020 Jan;30(1):120-136. doi: 10.1111/bpa.12761. Epub 2019 Jul 16. Brain Pathol. 2020. PMID: 31264746 Free PMC article.
Kidins220 deficiency causes ventriculomegaly via SNX27-retromer-dependent AQP4 degradation.
Del Puerto A, Pose-Utrilla J, Simón-García A, López-Menéndez C, Jiménez AJ, Porlan E, Pajuelo LSM, Cano-García G, Martí-Prado B, Sebastián-Serrano Á, Sánchez-Carralero MP, Cesca F, Schiavo G, Ferrer I, Fariñas I, Campanero MR, Iglesias T. Del Puerto A, et al. Among authors: iglesias t. Mol Psychiatry. 2021 Nov;26(11):6411-6426. doi: 10.1038/s41380-021-01127-9. Epub 2021 May 17. Mol Psychiatry. 2021. PMID: 34002021 Free PMC article.
Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-I.
Fernandez AM, Hernandez-Garzón E, Perez-Domper P, Perez-Alvarez A, Mederos S, Matsui T, Santi A, Trueba-Saiz A, García-Guerra L, Pose-Utrilla J, Fielitz J, Olson EN, Fernandez de la Rosa R, Garcia Garcia L, Pozo MA, Iglesias T, Araque A, Soya H, Perea G, Martin ED, Torres Aleman I. Fernandez AM, et al. Among authors: iglesias t. Diabetes. 2017 Jan;66(1):64-74. doi: 10.2337/db16-0861. Epub 2016 Oct 10. Diabetes. 2017. PMID: 27999108
126 results