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The discovery of N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide (Macitentan), an orally active, potent dual endothelin receptor antagonist.
Bolli MH, Boss C, Binkert C, Buchmann S, Bur D, Hess P, Iglarz M, Meyer S, Rein J, Rey M, Treiber A, Clozel M, Fischli W, Weller T. Bolli MH, et al. Among authors: iglarz m. J Med Chem. 2012 Sep 13;55(17):7849-61. doi: 10.1021/jm3009103. Epub 2012 Aug 16. J Med Chem. 2012. PMID: 22862294
Mechanisms of ET-1-induced endothelial dysfunction.
Iglarz M, Clozel M. Iglarz M, et al. J Cardiovasc Pharmacol. 2007 Dec;50(6):621-8. doi: 10.1097/FJC.0b013e31813c6cc3. J Cardiovasc Pharmacol. 2007. PMID: 18091577 Review.
Chymase: a multifunctional player in pulmonary hypertension associated with lung fibrosis.
Kosanovic D, Luitel H, Dahal BK, Cornitescu T, Janssen W, Danser AH, Garrelds IM, De Mey JG, Fazzi G, Schiffers P, Iglarz M, Fischli W, Ghofrani HA, Weissmann N, Grimminger F, Seeger W, Reiss I, Schermuly RT. Kosanovic D, et al. Among authors: iglarz m. Eur Respir J. 2015 Oct;46(4):1084-94. doi: 10.1183/09031936.00018215. Epub 2015 Jun 25. Eur Respir J. 2015. PMID: 26113671 Free article.
Comparison of Macitentan and Bosentan on Right Ventricular Remodeling in a Rat Model of Non-vasoreactive Pulmonary Hypertension.
Iglarz M, Landskroner K, Bauer Y, Vercauteren M, Rey M, Renault B, Studer R, Vezzali E, Freti D, Hadana H, Schläpfer M, Cattaneo C, Bortolamiol C, Weber E, Whitby BR, Delahaye S, Wanner D, Steiner P, Nayler O, Hess P, Clozel M. Iglarz M, et al. J Cardiovasc Pharmacol. 2015 Nov;66(5):457-67. doi: 10.1097/FJC.0000000000000296. J Cardiovasc Pharmacol. 2015. PMID: 26230396 Free PMC article.
55 results