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Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage.
Rosado-Ramos R, Poças GM, Marques D, Foito A, M Sevillano D, Lopes-da-Silva M, Gonçalves LG, Menezes R, Ottens M, Stewart D, Ibáñez de Opakua A, Zweckstetter M, Seabra MC, Mendes CS, Outeiro TF, Domingos PM, Santos CN. Rosado-Ramos R, et al. Among authors: ibanez de opakua a. Nat Commun. 2023 Apr 6;14(1):1918. doi: 10.1038/s41467-023-37561-2. Nat Commun. 2023. PMID: 37024503 Free PMC article.
Multimodal interactions drive chromatin phase separation and compaction.
Ukmar-Godec T, Cima-Omori MS, Yerkesh Z, Eswara K, Yu T, Ramesh R, Riviere G, Ibanez de Opakua A, Fischle W, Zweckstetter M. Ukmar-Godec T, et al. Among authors: ibanez de opakua a. Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2308858120. doi: 10.1073/pnas.2308858120. Epub 2023 Dec 4. Proc Natl Acad Sci U S A. 2023. PMID: 38048471 Free PMC article.
Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer.
Zhao J, DiGiacomo V, Ferreras-Gutierrez M, Dastjerdi S, Ibáñez de Opakua A, Park JC, Luebbers A, Chen Q, Beeler A, Blanco FJ, Garcia-Marcos M. Zhao J, et al. Among authors: ibanez de opakua a. Proc Natl Acad Sci U S A. 2023 May 2;120(18):e2213140120. doi: 10.1073/pnas.2213140120. Epub 2023 Apr 25. Proc Natl Acad Sci U S A. 2023. PMID: 37098067 Free PMC article.
Molecular interactions of FG nucleoporin repeats at high resolution.
Ibáñez de Opakua A, Geraets JA, Frieg B, Dienemann C, Savastano A, Rankovic M, Cima-Omori MS, Schröder GF, Zweckstetter M. Ibáñez de Opakua A, et al. Nat Chem. 2022 Nov;14(11):1278-1285. doi: 10.1038/s41557-022-01035-7. Epub 2022 Sep 22. Nat Chem. 2022. PMID: 36138110 Free PMC article.
A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity.
Kumar ST, Mahul-Mellier AL, Hegde RN, Rivière G, Moons R, Ibáñez de Opakua A, Magalhães P, Rostami I, Donzelli S, Sobott F, Zweckstetter M, Lashuel HA. Kumar ST, et al. Among authors: ibanez de opakua a. Sci Adv. 2022 Apr 29;8(17):eabn0044. doi: 10.1126/sciadv.abn0044. Epub 2022 Apr 29. Sci Adv. 2022. PMID: 35486726 Free PMC article.
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