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The p12 subunit of human polymerase δ uses an atypical PIP box for molecular recognition of proliferating cell nuclear antigen (PCNA).
Gonzalez-Magaña A, Ibáñez de Opakua A, Romano-Moreno M, Murciano-Calles J, Merino N, Luque I, Rojas AL, Onesti S, Blanco FJ, De Biasio A. Gonzalez-Magaña A, et al. Among authors: de biasio a, ibanez de opakua a. J Biol Chem. 2019 Mar 15;294(11):3947-3956. doi: 10.1074/jbc.RA118.006391. Epub 2019 Jan 17. J Biol Chem. 2019. PMID: 30655288 Free PMC article.
TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress.
Hoffmann S, Smedegaard S, Nakamura K, Mortuza GB, Räschle M, Ibañez de Opakua A, Oka Y, Feng Y, Blanco FJ, Mann M, Montoya G, Groth A, Bekker-Jensen S, Mailand N. Hoffmann S, et al. Among authors: ibanez de opakua a. J Cell Biol. 2016 Jan 4;212(1):63-75. doi: 10.1083/jcb.201506071. Epub 2015 Dec 28. J Cell Biol. 2016. PMID: 26711499 Free PMC article.
Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer.
Zhao J, DiGiacomo V, Ferreras-Gutierrez M, Dastjerdi S, Ibáñez de Opakua A, Park JC, Luebbers A, Chen Q, Beeler A, Blanco FJ, Garcia-Marcos M. Zhao J, et al. Among authors: ibanez de opakua a. Proc Natl Acad Sci U S A. 2023 May 2;120(18):e2213140120. doi: 10.1073/pnas.2213140120. Epub 2023 Apr 25. Proc Natl Acad Sci U S A. 2023. PMID: 37098067 Free PMC article.
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