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Molecular basis for substrate recruitment to the PRMT5 methylosome.
Mulvaney KM, Blomquist C, Acharya N, Li R, Ranaghan MJ, O'Keefe M, Rodriguez DJ, Young MJ, Kesar D, Pal D, Stokes M, Nelson AJ, Jain SS, Yang A, Mullin-Bernstein Z, Columbus J, Bozal FK, Skepner A, Raymond D, LaRussa S, McKinney DC, Freyzon Y, Baidi Y, Porter D, Aguirre AJ, Ianari A, McMillan B, Sellers WR. Mulvaney KM, et al. Among authors: ianari a. Mol Cell. 2021 Sep 2;81(17):3481-3495.e7. doi: 10.1016/j.molcel.2021.07.019. Epub 2021 Aug 5. Mol Cell. 2021. PMID: 34358446 Free PMC article.
Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction.
McKinney DC, McMillan BJ, Ranaghan MJ, Moroco JA, Brousseau M, Mullin-Bernstein Z, O'Keefe M, McCarren P, Mesleh MF, Mulvaney KM, Robinson F, Singh R, Bajrami B, Wagner FF, Hilgraf R, Drysdale MJ, Campbell AJ, Skepner A, Timm DE, Porter D, Kaushik VK, Sellers WR, Ianari A. McKinney DC, et al. Among authors: ianari a. J Med Chem. 2021 Aug 12;64(15):11148-11168. doi: 10.1021/acs.jmedchem.1c00507. Epub 2021 Aug 3. J Med Chem. 2021. PMID: 34342224 Free PMC article.
Targeted Covalent Inhibition of Plasmodium FK506 Binding Protein 35.
Atack TC, Raymond DD, Blomquist CA, Pasaje CF, McCarren PR, Moroco J, Befekadu HB, Robinson FP, Pal D, Esherick LY, Ianari A, Niles JC, Sellers WR. Atack TC, et al. Among authors: ianari a. ACS Med Chem Lett. 2020 Sep 1;11(11):2131-2138. doi: 10.1021/acsmedchemlett.0c00272. eCollection 2020 Nov 12. ACS Med Chem Lett. 2020. PMID: 33209191 Free PMC article.
Systematic profiling of conditional degron tag technologies for target validation studies.
Bondeson DP, Mullin-Bernstein Z, Oliver S, Skipper TA, Atack TC, Bick N, Ching M, Guirguis AA, Kwon J, Langan C, Millson D, Paolella BR, Tran K, Wie SJ, Vazquez F, Tothova Z, Golub TR, Sellers WR, Ianari A. Bondeson DP, et al. Among authors: ianari a. Nat Commun. 2022 Sep 20;13(1):5495. doi: 10.1038/s41467-022-33246-4. Nat Commun. 2022. PMID: 36127368 Free PMC article.
The retinoblastoma protein induces apoptosis directly at the mitochondria.
Hilgendorf KI, Leshchiner ES, Nedelcu S, Maynard MA, Calo E, Ianari A, Walensky LD, Lees JA. Hilgendorf KI, et al. Among authors: ianari a. Genes Dev. 2013 May 1;27(9):1003-15. doi: 10.1101/gad.211326.112. Epub 2013 Apr 25. Genes Dev. 2013. PMID: 23618872 Free PMC article.
15 results