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Elevated NSD3 histone methylation activity drives squamous cell lung cancer.
Yuan G, Flores NM, Hausmann S, Lofgren SM, Kharchenko V, Angulo-Ibanez M, Sengupta D, Lu X, Czaban I, Azhibek D, Vicent S, Fischle W, Jaremko M, Fang B, Wistuba II, Chua KF, Roth JA, Minna JD, Shao NY, Jaremko Ł, Mazur PK, Gozani O. Yuan G, et al. Nature. 2021 Feb;590(7846):504-508. doi: 10.1038/s41586-020-03170-y. Epub 2021 Feb 3. Nature. 2021. PMID: 33536620 Free PMC article.
SIRT6: Novel Mechanisms and Links to Aging and Disease.
Tasselli L, Zheng W, Chua KF. Tasselli L, et al. Trends Endocrinol Metab. 2017 Mar;28(3):168-185. doi: 10.1016/j.tem.2016.10.002. Epub 2016 Nov 9. Trends Endocrinol Metab. 2017. PMID: 27836583 Free PMC article. Review.
SIRT7 clears the way for DNA repair.
Paredes S, Chua KF. Paredes S, et al. EMBO J. 2016 Jul 15;35(14):1483-5. doi: 10.15252/embj.201694904. Epub 2016 Jun 14. EMBO J. 2016. PMID: 27302089 Free PMC article.
SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease.
Shin J, He M, Liu Y, Paredes S, Villanova L, Brown K, Qiu X, Nabavi N, Mohrin M, Wojnoonski K, Li P, Cheng HL, Murphy AJ, Valenzuela DM, Luo H, Kapahi P, Krauss R, Mostoslavsky R, Yancopoulos GD, Alt FW, Chua KF, Chen D. Shin J, et al. Cell Rep. 2013 Nov 14;5(3):654-665. doi: 10.1016/j.celrep.2013.10.007. Epub 2013 Nov 7. Cell Rep. 2013. PMID: 24210820 Free PMC article.