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Page 1
African Hydroclimate During the Early Eocene From the DeepMIP Simulations.
Williams CJR, Lunt DJ, Salzmann U, Reichgelt T, Inglis GN, Greenwood DR, Chan WL, Abe-Ouchi A, Donnadieu Y, Hutchinson DK, de Boer AM, Ladant JB, Morozova PA, Niezgodzki I, Knorr G, Steinig S, Zhang Z, Zhu J, Huber M, Otto-Bliesner BL. Williams CJR, et al. Among authors: hutchinson dk. Paleoceanogr Paleoclimatol. 2022 May;37(5):e2022PA004419. doi: 10.1029/2022PA004419. Epub 2022 May 16. Paleoceanogr Paleoclimatol. 2022. PMID: 35915854 Free PMC article.
Rapid global ocean-atmosphere response to Southern Ocean freshening during the last glacial.
Turney CSM, Jones RT, Phipps SJ, Thomas Z, Hogg A, Kershaw AP, Fogwill CJ, Palmer J, Bronk Ramsey C, Adolphi F, Muscheler R, Hughen KA, Staff RA, Grosvenor M, Golledge NR, Rasmussen SO, Hutchinson DK, Haberle S, Lorrey A, Boswijk G, Cooper A. Turney CSM, et al. Among authors: hutchinson dk. Nat Commun. 2017 Sep 12;8(1):520. doi: 10.1038/s41467-017-00577-6. Nat Commun. 2017. PMID: 28900099 Free PMC article.
Highlights of the Structure-Activity Relationships of Benzimidazole Linked Pyrrolidines Leading to the Discovery of the Hepatitis C Virus NS5A Inhibitor Pibrentasvir (ABT-530).
Wagner R, Randolph JT, Patel SV, Nelson L, Matulenko MA, Keddy R, Pratt JK, Liu D, Krueger AC, Donner PL, Hutchinson DK, Flentge C, Betebenner D, Rockway T, Maring CJ, Ng TI, Krishnan P, Pilot-Matias T, Collins C, Panchal N, Reisch T, Dekhtyar T, Mondal R, Stolarik DF, Gao Y, Gao W, Beno DA, Kati WM. Wagner R, et al. Among authors: hutchinson dk. J Med Chem. 2018 May 10;61(9):4052-4066. doi: 10.1021/acs.jmedchem.8b00082. Epub 2018 Apr 23. J Med Chem. 2018. PMID: 29653491
Discovery of fluorobenzimidazole HCV NS5A inhibitors.
Randolph JT, Flentge CA, Donner P, Rockway TW, Patel SV, Nelson L, Hutchinson DK, Mondal R, Mistry N, Reisch T, Dekhtyar T, Krishnan P, Pilot-Matias T, Stolarik DF, Beno DWA, Wagner R, Maring C, Kati WM. Randolph JT, et al. Among authors: hutchinson dk. Bioorg Med Chem Lett. 2016 Nov 15;26(22):5462-5467. doi: 10.1016/j.bmcl.2016.10.030. Epub 2016 Oct 13. Bioorg Med Chem Lett. 2016. PMID: 27780635
Aryl uracil inhibitors of hepatitis C virus NS5B polymerase: synthesis and characterization of analogs with a fused 5,6-bicyclic ring motif.
Krueger AC, Randolph JT, DeGoey DA, Donner PL, Flentge CA, Hutchinson DK, Liu D, Motter CE, Rockway TW, Wagner R, Beno DW, Koev G, Lim HB, Beyer JM, Mondal R, Liu Y, Kati WM, Longenecker KL, Molla A, Stewart KD, Maring CJ. Krueger AC, et al. Among authors: hutchinson dk. Bioorg Med Chem Lett. 2013 Jun 15;23(12):3487-90. doi: 10.1016/j.bmcl.2013.04.057. Epub 2013 May 1. Bioorg Med Chem Lett. 2013. PMID: 23664214
Hepatitis C NS5B polymerase inhibitors: functional equivalents for the benzothiadiazine moiety.
Hutchinson DK, Flentge CA, Donner PL, Wagner R, Maring CJ, Kati WM, Liu Y, Masse SV, Middleton T, Mo H, Montgomery D, Jiang WW, Koev G, Beno DW, Stewart KD, Stoll VS, Molla A, Kempf DJ. Hutchinson DK, et al. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1876-9. doi: 10.1016/j.bmcl.2010.12.067. Epub 2011 Jan 13. Bioorg Med Chem Lett. 2011. PMID: 21316235
27 results