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LKB1-SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition.
Proteau S, Krossa I, Husser C, Guéguinou M, Sella F, Bille K, Irondelle M, Dalmasso M, Barouillet T, Cheli Y, Pisibon C, Arrighi N, Nahon-Estève S, Martel A, Gastaud L, Lassalle S, Mignen O, Brest P, Mazure NM, Bost F, Baillif S, Landreville S, Turcotte S, Hasson D, Carcamo S, Vandier C, Bernstein E, Yvan-Charvet L, Levesque MP, Ballotti R, Bertolotto C, Strub T. Proteau S, et al. Among authors: husser c. EMBO Mol Med. 2023 Dec 7;15(12):e17719. doi: 10.15252/emmm.202317719. Epub 2023 Nov 15. EMBO Mol Med. 2023. PMID: 37966164 Free PMC article.
Single-cell RNA sequencing reveals intratumoral heterogeneity in primary uveal melanomas and identifies HES6 as a driver of the metastatic disease.
Pandiani C, Strub T, Nottet N, Cheli Y, Gambi G, Bille K, Husser C, Dalmasso M, Béranger G, Lassalle S, Magnone V, Pédeutour F, Irondelle M, Maschi C, Nahon-Estève S, Martel A, Caujolle JP, Hofman P, LeBrigand K, Davidson I, Baillif S, Barbry P, Ballotti R, Bertolotto C. Pandiani C, et al. Among authors: husser c. Cell Death Differ. 2021 Jun;28(6):1990-2000. doi: 10.1038/s41418-020-00730-7. Epub 2021 Jan 18. Cell Death Differ. 2021. PMID: 33462406 Free PMC article.
Regulation of Melanogenesis by the Amino Acid Transporter SLC7A5.
Gaudel C, Soysouvanh F, Leclerc J, Bille K, Husser C, Montcriol F, Bertolotto C, Ballotti R. Gaudel C, et al. Among authors: husser c. J Invest Dermatol. 2020 Nov;140(11):2253-2259.e4. doi: 10.1016/j.jid.2020.03.941. Epub 2020 Mar 30. J Invest Dermatol. 2020. PMID: 32240722 Free article.
Investigating discovery strategies and pharmacological properties of stereodefined phosphorodithioate LNA gapmers.
Duschmalé J, Schäublin A, Funder E, Schmidt S, Kiełpiński ŁJ, Nymark H, Jensen K, Koch T, Duschmalé M, Koller E, Møller MR, Schadt S, Husser C, Brink A, Sewing S, Minz T, Wengel J, Bleicher K, Li M. Duschmalé J, et al. Among authors: husser c. Mol Ther Nucleic Acids. 2022 Jun 22;29:176-188. doi: 10.1016/j.omtn.2022.06.010. eCollection 2022 Sep 13. Mol Ther Nucleic Acids. 2022. PMID: 35860384 Free PMC article.
Addressing Today's Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam.
Fowler S, Brink A, Cleary Y, Günther A, Heinig K, Husser C, Kletzl H, Kratochwil N, Mueller L, Savage M, Stillhart C, Tuerck D, Ullah M, Umehara K, Poirier A. Fowler S, et al. Among authors: husser c. Drug Metab Dispos. 2022 Jan;50(1):65-75. doi: 10.1124/dmd.121.000563. Epub 2021 Oct 7. Drug Metab Dispos. 2022. PMID: 34620695 Review.
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