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Page 1
Pyridazine-derived γ-secretase modulators.
Wan Z, Hall A, Jin Y, Xiang JN, Yang E, Eatherton A, Smith B, Yang G, Yu H, Wang J, Ye L, Lau LF, Yang T, Mitchell W, Cai W, Zhang X, Sang Y, Wang Y, Tong Z, Cheng Z, Hussain I, Elliott JD, Matsuoka Y. Wan Z, et al. Among authors: hussain i. Bioorg Med Chem Lett. 2011 Jul 1;21(13):4016-9. doi: 10.1016/j.bmcl.2011.04.143. Epub 2011 May 13. Bioorg Med Chem Lett. 2011. PMID: 21636276
Piperidine-derived gamma-secretase modulators.
Hall A, Elliott RL, Giblin GM, Hussain I, Musgrave J, Naylor A, Sasse R, Smith B. Hall A, et al. Among authors: hussain i. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1306-11. doi: 10.1016/j.bmcl.2009.08.072. Epub 2009 Aug 23. Bioorg Med Chem Lett. 2010. PMID: 20056541
Pyridine-derived γ-secretase modulators.
Wan Z, Hall A, Sang Y, Xiang JN, Yang E, Smith B, Harrison DC, Yang G, Yu H, Price HS, Wang J, Hawkins J, Lau LF, Johnson MR, Li T, Zhao W, Mitchell WL, Su X, Zhang X, Zhou Y, Jin Y, Tong Z, Cheng Z, Hussain I, Elliott JD, Matsuoka Y. Wan Z, et al. Among authors: hussain i. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4832-5. doi: 10.1016/j.bmcl.2011.06.042. Epub 2011 Jun 17. Bioorg Med Chem Lett. 2011. PMID: 21742495
Orally bioavailable and brain-penetrant pyridazine and pyridine-derived γ-secretase modulators reduced amyloidogenic Aβ peptides in vivo.
Huang Y, Li T, Eatherton A, Mitchell WL, Rong N, Ye L, Yang XJ, Jin S, Ding Y, Zhang J, Li Y, Wu Y, Jin Y, Sang Y, Cheng Z, Browne ER, Harrison DC, Hussain I, Wan Z, Hall A, Lau LF, Matsuoka Y. Huang Y, et al. Among authors: hussain i. Neuropharmacology. 2013 Jul;70:278-86. doi: 10.1016/j.neuropharm.2013.02.003. Epub 2013 Feb 26. Neuropharmacology. 2013. PMID: 23485401
TASTPM mice expressing amyloid precursor protein and presenilin-1 mutant transgenes are sensitive to γ-secretase modulation and amyloid-β₄₂ lowering by GSM-10h.
Hussain I, Harrison DC, Hawkins J, Chapman T, Marshall I, Facci L, Ahmed S, Brackenborough K, Skaper SD, Mead TL, Smith BB, Giblin GM, Hall A, Gonzalez MI, Richardson JC. Hussain I, et al. Neurodegener Dis. 2011;8(1-2):15-24. doi: 10.1159/000313903. Epub 2010 Aug 4. Neurodegener Dis. 2011. PMID: 20689247
BACE-1 hydroxyethylamine inhibitors using novel edge-to-face interaction with Arg-296.
Clarke B, Cutler L, Demont E, Dingwall C, Dunsdon R, Hawkins J, Howes C, Hussain I, Maile G, Matico R, Mosley J, Naylor A, O'Brien A, Redshaw S, Rowland P, Soleil V, Smith KJ, Sweitzer S, Theobald P, Vesey D, Walter DS, Wayne G. Clarke B, et al. Among authors: hussain i. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4639-44. doi: 10.1016/j.bmcl.2010.05.111. Epub 2010 Jun 8. Bioorg Med Chem Lett. 2010. PMID: 20579874
Second generation of BACE-1 inhibitors part 3: Towards non hydroxyethylamine transition state mimetics.
Charrier N, Clarke B, Cutler L, Demont E, Dingwall C, Dunsdon R, Hawkins J, Howes C, Hubbard J, Hussain I, Maile G, Matico R, Mosley J, Naylor A, O'Brien A, Redshaw S, Rowland P, Soleil V, Smith KJ, Sweitzer S, Theobald P, Vesey D, Walter DS, Wayne G. Charrier N, et al. Among authors: hussain i. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3674-8. doi: 10.1016/j.bmcl.2009.03.149. Epub 2009 Apr 5. Bioorg Med Chem Lett. 2009. PMID: 19406640
BACE-1 inhibitors part 1: identification of novel hydroxy ethylamines (HEAs).
Clarke B, Demont E, Dingwall C, Dunsdon R, Faller A, Hawkins J, Hussain I, MacPherson D, Maile G, Matico R, Milner P, Mosley J, Naylor A, O'Brien A, Redshaw S, Riddell D, Rowland P, Soleil V, Smith KJ, Stanway S, Stemp G, Sweitzer S, Theobald P, Vesey D, Walter DS, Ward J, Wayne G. Clarke B, et al. Among authors: hussain i. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1011-6. doi: 10.1016/j.bmcl.2007.12.017. Epub 2007 Dec 15. Bioorg Med Chem Lett. 2008. PMID: 18171614
1,259 results