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Functional screening and rational design of compounds targeting GPR132 to treat diabetes.
Nat Metab. 2023 Oct;5(10):1726-1746. doi: 10.1038/s42255-023-00899-4. Epub 2023 Sep 28.
Nat Metab. 2023.
PMID: 37770763
Discovery of 2-(furan-2-ylmethylene)hydrazine-1-carbothioamide derivatives as novel inhibitors of SARS-CoV-2 main protease.
Dou X, Sun Q, Xu G, Liu Y, Zhang C, Wang B, Lu Y, Guo Z, Su L, Huo T, Zhao X, Wang C, Yu Z, Song S, Zhang L, Liu Z, Lai L, Jiao N.
Dou X, et al.
Eur J Med Chem. 2022 Aug 5;238:114508. doi: 10.1016/j.ejmech.2022.114508. Epub 2022 Jun 3.
Eur J Med Chem. 2022.
PMID: 35688005
Free PMC article.
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Late-stage modification of bioactive compounds: Improving druggability through efficient molecular editing.
Huo T, Zhao X, Cheng Z, Wei J, Zhu M, Dou X, Jiao N.
Huo T, et al.
Acta Pharm Sin B. 2024 Mar;14(3):1030-1076. doi: 10.1016/j.apsb.2023.11.021. Epub 2023 Nov 18.
Acta Pharm Sin B. 2024.
PMID: 38487004
Free PMC article.
Review.
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Discovery of novel and selective farnesoid X receptor antagonists through structure-based virtual screening, preliminary structure-activity relationship study, and biological evaluation.
Dou X, Huo T, Liu Y, Pang Z, Su L, Zhao X, Peng X, Liu Z, Zhang L, Jiao N.
Dou X, et al.
Eur J Med Chem. 2024 Apr 5;269:116323. doi: 10.1016/j.ejmech.2024.116323. Epub 2024 Mar 18.
Eur J Med Chem. 2024.
PMID: 38547735
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Paclitaxel induces apoptosis through the TAK1-JNK activation pathway.
Yu-Wei D, Li ZS, Xiong SM, Huang G, Luo YF, Huo TY, Zhou MH, Zheng YW.
Yu-Wei D, et al. Among authors: huo ty.
FEBS Open Bio. 2020 Aug;10(8):1655-1667. doi: 10.1002/2211-5463.12917. Epub 2020 Jul 31.
FEBS Open Bio. 2020.
PMID: 32594651
Free PMC article.
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