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p63 uses a switch-like mechanism to set the threshold for induction of apoptosis.
Gebel J, Tuppi M, Chaikuad A, Hötte K, Schröder M, Schulz L, Löhr F, Gutfreund N, Finke F, Henrich E, Mezhyrova J, Lehnert R, Pampaloni F, Hummer G, Stelzer EHK, Knapp S, Dötsch V. Gebel J, et al. Among authors: hummer g. Nat Chem Biol. 2020 Oct;16(10):1078-1086. doi: 10.1038/s41589-020-0600-3. Epub 2020 Jul 27. Nat Chem Biol. 2020. PMID: 32719556
The molecular recognition of phosphatidic acid by an amphipathic helix in Opi1.
Hofbauer HF, Gecht M, Fischer SC, Seybert A, Frangakis AS, Stelzer EHK, Covino R, Hummer G, Ernst R. Hofbauer HF, et al. Among authors: hummer g. J Cell Biol. 2018 Sep 3;217(9):3109-3126. doi: 10.1083/jcb.201802027. Epub 2018 Jun 25. J Cell Biol. 2018. PMID: 29941475 Free PMC article.
Conformation space of a heterodimeric ABC exporter under turnover conditions.
Hofmann S, Januliene D, Mehdipour AR, Thomas C, Stefan E, Brüchert S, Kuhn BT, Geertsma ER, Hummer G, Tampé R, Moeller A. Hofmann S, et al. Among authors: hummer g. Nature. 2019 Jul;571(7766):580-583. doi: 10.1038/s41586-019-1391-0. Epub 2019 Jul 17. Nature. 2019. PMID: 31316210 Free PMC article.
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity.
Shin D, Mukherjee R, Grewe D, Bojkova D, Baek K, Bhattacharya A, Schulz L, Widera M, Mehdipour AR, Tascher G, Geurink PP, Wilhelm A, van der Heden van Noort GJ, Ovaa H, Müller S, Knobeloch KP, Rajalingam K, Schulman BA, Cinatl J, Hummer G, Ciesek S, Dikic I. Shin D, et al. Among authors: hummer g. Nature. 2020 Nov;587(7835):657-662. doi: 10.1038/s41586-020-2601-5. Epub 2020 Jul 29. Nature. 2020. PMID: 32726803 Free PMC article.
Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation.
Gruijs da Silva LA, Simonetti F, Hutten S, Riemenschneider H, Sternburg EL, Pietrek LM, Gebel J, Dötsch V, Edbauer D, Hummer G, Stelzl LS, Dormann D. Gruijs da Silva LA, et al. Among authors: hummer g. EMBO J. 2022 Apr 19;41(8):e108443. doi: 10.15252/embj.2021108443. Epub 2022 Feb 3. EMBO J. 2022. PMID: 35112738 Free PMC article.
Dissecting the conformational complexity and mechanism of a bacterial heme transporter.
Wu D, Mehdipour AR, Finke F, Goojani HG, Groh RR, Grund TN, Reichhart TMB, Zimmermann R, Welsch S, Bald D, Shepherd M, Hummer G, Safarian S. Wu D, et al. Among authors: hummer g. Nat Chem Biol. 2023 Aug;19(8):992-1003. doi: 10.1038/s41589-023-01314-5. Epub 2023 Apr 24. Nat Chem Biol. 2023. PMID: 37095238 Free PMC article.
Ubiquitination regulates ER-phagy and remodelling of endoplasmic reticulum.
González A, Covarrubias-Pinto A, Bhaskara RM, Glogger M, Kuncha SK, Xavier A, Seemann E, Misra M, Hoffmann ME, Bräuning B, Balakrishnan A, Qualmann B, Dötsch V, Schulman BA, Kessels MM, Hübner CA, Heilemann M, Hummer G, Dikić I. González A, et al. Among authors: hummer g. Nature. 2023 Jun;618(7964):394-401. doi: 10.1038/s41586-023-06089-2. Epub 2023 May 24. Nature. 2023. PMID: 37225996 Free PMC article.
325 results