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The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts.
Friščić J, Böttcher M, Reinwald C, Bruns H, Wirth B, Popp SJ, Walker KI, Ackermann JA, Chen X, Turner J, Zhu H, Seyler L, Euler M, Kirchner P, Krüger R, Ekici AB, Major T, Aust O, Weidner D, Fischer A, Andes FT, Stanojevic Z, Trajkovic V, Herrmann M, Korb-Pap A, Wank I, Hess A, Winter J, Wixler V, Distler J, Steiner G, Kiener HP, Frey B, Kling L, Raza K, Frey S, Kleyer A, Bäuerle T, Hughes TR, Grüneboom A, Steffen U, Krönke G, Croft AP, Filer A, Köhl J, Klein K, Buckley CD, Schett G, Mougiakakos D, Hoffmann MH. Friščić J, et al. Among authors: hughes tr. Immunity. 2021 May 11;54(5):1002-1021.e10. doi: 10.1016/j.immuni.2021.03.003. Epub 2021 Mar 23. Immunity. 2021. PMID: 33761330 Free article.
C3-dependent mechanism of microglial priming relevant to multiple sclerosis.
Ramaglia V, Hughes TR, Donev RM, Ruseva MM, Wu X, Huitinga I, Baas F, Neal JW, Morgan BP. Ramaglia V, et al. Among authors: hughes tr. Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):965-70. doi: 10.1073/pnas.1111924109. Epub 2012 Jan 4. Proc Natl Acad Sci U S A. 2012. PMID: 22219359 Free PMC article.
Complementing the inflammasome.
Triantafilou M, Hughes TR, Morgan BP, Triantafilou K. Triantafilou M, et al. Among authors: hughes tr. Immunology. 2016 Feb;147(2):152-64. doi: 10.1111/imm.12556. Immunology. 2016. PMID: 26572245 Free PMC article. Review.
Therapeutic Intervention with Anti-Complement Component 5 Antibody Does Not Reduce NASH but Does Attenuate Atherosclerosis and MIF Concentrations in Ldlr-/-.Leiden Mice.
Seidel F, Kleemann R, van Duyvenvoorde W, van Trigt N, Keijzer N, van der Kooij S, van Kooten C, Verschuren L, Menke A, Kiliaan AJ, Winter J, Hughes TR, Morgan BP, Baas F, Fluiter K, Morrison MC. Seidel F, et al. Among authors: hughes tr. Int J Mol Sci. 2022 Sep 14;23(18):10736. doi: 10.3390/ijms231810736. Int J Mol Sci. 2022. PMID: 36142647 Free PMC article.
274 results