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6,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 integrase inhibitors.
Zhao XZ, Maddali K, Smith SJ, Métifiot M, Johnson BC, Marchand C, Hughes SH, Pommier Y, Burke TR Jr. Zhao XZ, et al. Among authors: hughes sh. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7309-13. doi: 10.1016/j.bmcl.2012.10.088. Epub 2012 Oct 27. Bioorg Med Chem Lett. 2012. PMID: 23149229 Free PMC article.
Crystal structures for HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: a new class of non-nucleoside inhibitors effective against a broad range of drug-resistant strains.
Himmel DM, Das K, Clark AD Jr, Hughes SH, Benjahad A, Oumouch S, Guillemont J, Coupa S, Poncelet A, Csoka I, Meyer C, Andries K, Nguyen CH, Grierson DS, Arnold E. Himmel DM, et al. Among authors: hughes sh. J Med Chem. 2005 Dec 1;48(24):7582-91. doi: 10.1021/jm0500323. J Med Chem. 2005. PMID: 16302798
Synthesis, biological activity, and crystal structure of potent nonnucleoside inhibitors of HIV-1 reverse transcriptase that retain activity against mutant forms of the enzyme.
Morningstar ML, Roth T, Farnsworth DW, Smith MK, Watson K, Buckheit RW Jr, Das K, Zhang W, Arnold E, Julias JG, Hughes SH, Michejda CJ. Morningstar ML, et al. Among authors: hughes sh. J Med Chem. 2007 Aug 23;50(17):4003-15. doi: 10.1021/jm060103d. Epub 2007 Jul 31. J Med Chem. 2007. PMID: 17663538 Free PMC article.
The nucleoside analogue D-carba T blocks HIV-1 reverse transcription.
Boyer PL, Vu BC, Ambrose Z, Julias JG, Warnecke S, Liao C, Meier C, Marquez VE, Hughes SH. Boyer PL, et al. Among authors: hughes sh. J Med Chem. 2009 Sep 10;52(17):5356-64. doi: 10.1021/jm801176e. J Med Chem. 2009. PMID: 19678643 Free PMC article.
Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration.
Ferris AL, Wu X, Hughes CM, Stewart C, Smith SJ, Milne TA, Wang GG, Shun MC, Allis CD, Engelman A, Hughes SH. Ferris AL, et al. Among authors: hughes cm, hughes sh. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3135-40. doi: 10.1073/pnas.0914142107. Epub 2010 Feb 1. Proc Natl Acad Sci U S A. 2010. PMID: 20133638 Free PMC article.
385 results