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IL-10 dampens antitumor immunity and promotes liver metastasis via PD-L1 induction.
Shiri AM, Zhang T, Bedke T, Zazara DE, Zhao L, Lücke J, Sabihi M, Fazio A, Zhang S, Tauriello DVF, Batlle E, Steglich B, Kempski J, Agalioti T, Nawrocki M, Xu Y, Riecken K, Liebold I, Brockmann L, Konczalla L, Bosurgi L, Mercanoglu B, Seeger P, Küsters N, Lykoudis PM, Heumann A, Arck PC, Fehse B, Busch P, Grotelüschen R, Mann O, Izbicki JR, Hackert T, Flavell RA, Gagliani N, Giannou AD, Huber S. Shiri AM, et al. Among authors: huber s. J Hepatol. 2024 Apr;80(4):634-644. doi: 10.1016/j.jhep.2023.12.015. Epub 2023 Dec 30. J Hepatol. 2024. PMID: 38160941 Free PMC article.
Checks and balances: IL-23 in the intestine.
Huber S, Flavell RA. Huber S, et al. Immunity. 2010 Aug 27;33(2):150-2. doi: 10.1016/j.immuni.2010.08.005. Immunity. 2010. PMID: 20732638 Free PMC article.
Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner.
Huber S, Gagliani N, Esplugues E, O'Connor W Jr, Huber FJ, Chaudhry A, Kamanaka M, Kobayashi Y, Booth CJ, Rudensky AY, Roncarolo MG, Battaglia M, Flavell RA. Huber S, et al. Among authors: huber fj. Immunity. 2011 Apr 22;34(4):554-65. doi: 10.1016/j.immuni.2011.01.020. Immunity. 2011. PMID: 21511184 Free PMC article.
Control of TH17 cells occurs in the small intestine.
Esplugues E, Huber S, Gagliani N, Hauser AE, Town T, Wan YY, O'Connor W Jr, Rongvaux A, Van Rooijen N, Haberman AM, Iwakura Y, Kuchroo VK, Kolls JK, Bluestone JA, Herold KC, Flavell RA. Esplugues E, et al. Among authors: huber s. Nature. 2011 Jul 17;475(7357):514-8. doi: 10.1038/nature10228. Nature. 2011. PMID: 21765430 Free PMC article.
The Intestine: where amazing things happen.
Gagliani N, Huber S, Flavell RA. Gagliani N, et al. Among authors: huber s. Cell Res. 2012 Feb;22(2):277-9. doi: 10.1038/cr.2011.204. Epub 2011 Dec 20. Cell Res. 2012. PMID: 22184010 Free PMC article.
1,723 results