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Insulin induces insulin receptor degradation in the liver through EphB4.
Liu X, Wang K, Hou S, Jiang Q, Ma C, Zhao Q, Kong L, Chen J, Wang Z, Zhang H, Yuan T, Li Y, Huan Y, Shen Z, Hu Z, Huang Z, Cui B, Li P. Liu X, et al. Among authors: huang z. Nat Metab. 2022 Sep;4(9):1202-1213. doi: 10.1038/s42255-022-00634-5. Epub 2022 Sep 21. Nat Metab. 2022. PMID: 36131205
Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer.
Suh JM, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, van Dijk TH, Havinga R, Fan W, Yin YQ, Yu RT, Liddle C, Atkins AR, Olefsky JM, Mohammadi M, Downes M, Evans RM. Suh JM, et al. Among authors: huang z. Nature. 2014 Sep 18;513(7518):436-9. doi: 10.1038/nature13540. Epub 2014 Jul 16. Nature. 2014. PMID: 25043058 Free PMC article.
Paracrine FGFs target skeletal muscle to exert potent anti-hyperglycemic effects.
Ying L, Wang L, Guo K, Hou Y, Li N, Wang S, Liu X, Zhao Q, Zhou J, Zhao L, Niu J, Chen C, Song L, Hou S, Kong L, Li X, Ren J, Li P, Mohammadi M, Huang Z. Ying L, et al. Among authors: huang z. Nat Commun. 2021 Dec 14;12(1):7256. doi: 10.1038/s41467-021-27584-y. Nat Commun. 2021. PMID: 34907199 Free PMC article.
Activating Adenosine Monophosphate-Activated Protein Kinase Mediates Fibroblast Growth Factor 1 Protection From Nonalcoholic Fatty Liver Disease in Mice.
Lin Q, Huang Z, Cai G, Fan X, Yan X, Liu Z, Zhao Z, Li J, Li J, Shi H, Kong M, Zheng MH, Conklin DJ, Epstein PN, Wintergerst KA, Mohammadi M, Cai L, Li X, Li Y, Tan Y. Lin Q, et al. Among authors: huang z. Hepatology. 2021 Jun;73(6):2206-2222. doi: 10.1002/hep.31568. Hepatology. 2021. PMID: 32965675 Free PMC article.
Curtailing FGF19's mitogenicity by suppressing its receptor dimerization ability.
Niu J, Zhao J, Wu J, Qiao G, Gu J, Zhou C, Li Q, Ying L, Wang D, Lin H, Li X, Mohammadi M, Huang Z. Niu J, et al. Among authors: huang z. Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):29025-29034. doi: 10.1073/pnas.2010984117. Epub 2020 Nov 3. Proc Natl Acad Sci U S A. 2020. PMID: 33144503 Free PMC article.
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