Huang TP - Search Results

1

Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity.

Neugebauer ME, Hsu A, Arbab M, Krasnow NA, McElroy AN, Pandey S, Doman JL, Huang TP, Raguram A, Banskota S, Newby GA, Tolar J, Osborn MJ, Liu DR. Neugebauer ME, et al. Among authors: huang tp. Nat Biotechnol. 2023 May;41(5):673-685. doi: 10.1038/s41587-022-01533-6. Epub 2022 Nov 10. Nat Biotechnol. 2023. PMID: 36357719 Free PMC article.

2

Continuous directed evolution of proteins with improved soluble expression.

Wang T, Badran AH, Huang TP, Liu DR. Wang T, et al. Among authors: huang tp. Nat Chem Biol. 2018 Oct;14(10):972-980. doi: 10.1038/s41589-018-0121-5. Epub 2018 Aug 20. Nat Chem Biol. 2018. PMID: 30127387 Free PMC article.

3

Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors.

Huang TP, Zhao KT, Miller SM, Gaudelli NM, Oakes BL, Fellmann C, Savage DF, Liu DR. Huang TP, et al. Nat Biotechnol. 2019 Jun;37(6):626-631. doi: 10.1038/s41587-019-0134-y. Epub 2019 May 20. Nat Biotechnol. 2019. PMID: 31110355 Free PMC article.

4

Author Correction: Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors.

Huang TP, Zhao KT, Miller SM, Gaudelli NM, Oakes BL, Fellmann C, Savage DF, Liu DR. Huang TP, et al. Nat Biotechnol. 2019 Jul;37(7):820. doi: 10.1038/s41587-019-0168-1. Nat Biotechnol. 2019. PMID: 31182863

5

High-throughput analysis of the activities of xCas9, SpCas9-NG and SpCas9 at matched and mismatched target sequences in human cells.

Kim HK, Lee S, Kim Y, Park J, Min S, Choi JW, Huang TP, Yoon S, Liu DR, Kim HH. Kim HK, et al. Among authors: huang tp. Nat Biomed Eng. 2020 Jan;4(1):111-124. doi: 10.1038/s41551-019-0505-1. Epub 2020 Jan 14. Nat Biomed Eng. 2020. PMID: 31937939

6

Continuous evolution of SpCas9 variants compatible with non-G PAMs.

Miller SM, Wang T, Randolph PB, Arbab M, Shen MW, Huang TP, Matuszek Z, Newby GA, Rees HA, Liu DR. Miller SM, et al. Among authors: huang tp. Nat Biotechnol. 2020 Apr;38(4):471-481. doi: 10.1038/s41587-020-0412-8. Epub 2020 Feb 10. Nat Biotechnol. 2020. PMID: 32042170 Free PMC article.

7

Precision genome editing using cytosine and adenine base editors in mammalian cells.

Huang TP, Newby GA, Liu DR. Huang TP, et al. Nat Protoc. 2021 Feb;16(2):1089-1128. doi: 10.1038/s41596-020-00450-9. Epub 2021 Jan 18. Nat Protoc. 2021. PMID: 33462442

8

Publisher Correction: Precision genome editing using cytosine and adenine base editors in mammalian cells.

Huang TP, Newby GA, Liu DR. Huang TP, et al. Nat Protoc. 2021 Dec;16(12):5740. doi: 10.1038/s41596-021-00525-1. Nat Protoc. 2021. PMID: 34789924 No abstract available.

9

CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNA.

Mok BY, Kotrys AV, Raguram A, Huang TP, Mootha VK, Liu DR. Mok BY, et al. Among authors: huang tp. Nat Biotechnol. 2022 Sep;40(9):1378-1387. doi: 10.1038/s41587-022-01256-8. Epub 2022 Apr 4. Nat Biotechnol. 2022. PMID: 35379961 Free PMC article.

10

Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors.

Davis JR, Wang X, Witte IP, Huang TP, Levy JM, Raguram A, Banskota S, Seidah NG, Musunuru K, Liu DR. Davis JR, et al. Among authors: huang tp. Nat Biomed Eng. 2022 Nov;6(11):1272-1283. doi: 10.1038/s41551-022-00911-4. Epub 2022 Jul 28. Nat Biomed Eng. 2022. PMID: 35902773 Free PMC article.

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