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HRS phosphorylation drives immunosuppressive exosome secretion and restricts CD8+ T-cell infiltration into tumors.
Guan L, Wu B, Li T, Beer LA, Sharma G, Li M, Lee CN, Liu S, Yang C, Huang L, Frederick DT, Boland GM, Shao G, Svitkina TM, Cai KQ, Chen F, Dong MQ, Mills GB, Schuchter LM, Karakousis GC, Mitchell TC, Flaherty KT, Speicher DW, Chen YH, Herlyn M, Amaravadi RK, Xu X, Guo W. Guan L, et al. Among authors: huang l. Nat Commun. 2022 Jul 14;13(1):4078. doi: 10.1038/s41467-022-31713-6. Nat Commun. 2022. PMID: 35835783 Free PMC article.
Costimulation of γδTCR and TLR7/8 promotes Vδ2 T-cell antitumor activity by modulating mTOR pathway and APC function.
Wang H, Chen H, Liu S, Zhang J, Lu H, Somasundaram R, Choi R, Zhang G, Ou L, Scholler J, Tian S, Dong L, Yeye G, Huang L, Connelly T, Li L, Huang A, Mitchell TC, Fan Y, June CH, Mills GB, Guo W, Herlyn M, Xu X. Wang H, et al. Among authors: huang l, huang a. J Immunother Cancer. 2021 Dec;9(12):e003339. doi: 10.1136/jitc-2021-003339. J Immunother Cancer. 2021. PMID: 34937742 Free PMC article.
Dichotomous and stable gamma delta T-cell number and function in healthy individuals.
Ou L, Wang H, Liu Q, Zhang J, Lu H, Luo L, Shi C, Lin S, Dong L, Guo Y, Huang L, Zhu J, Yin X, Huang AC, Karakousis G, Schuchter L, Amaravadi R, Zheng C, Fan Y, Guo W, Xu X. Ou L, et al. Among authors: huang l, huang ac. J Immunother Cancer. 2021 May;9(5):e002274. doi: 10.1136/jitc-2020-002274. J Immunother Cancer. 2021. PMID: 34011536 Free PMC article.
Targeting regulatory T cells for immunotherapy in melanoma.
Huang L, Guo Y, Liu S, Wang H, Zhu J, Ou L, Xu X. Huang L, et al. Mol Biomed. 2021;2(1):11. doi: 10.1186/s43556-021-00038-z. Epub 2021 Apr 19. Mol Biomed. 2021. PMID: 34806028 Free PMC article. Review.
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