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TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy.
Zehender A, Li YN, Lin NY, Stefanica A, Nüchel J, Chen CW, Hsu HH, Zhu H, Ding X, Huang J, Shen L, Györfi AH, Soare A, Rauber S, Bergmann C, Ramming A, Plomann M, Eckes B, Schett G, Distler JHW. Zehender A, et al. Among authors: huang j. Nat Commun. 2021 Jul 20;12(1):4404. doi: 10.1038/s41467-021-24601-y. Nat Commun. 2021. PMID: 34285225 Free PMC article.
The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis.
Zehender A, Huang J, Györfi AH, Matei AE, Trinh-Minh T, Xu X, Li YN, Chen CW, Lin J, Dees C, Beyer C, Gelse K, Zhang ZY, Bergmann C, Ramming A, Birchmeier W, Distler O, Schett G, Distler JHW. Zehender A, et al. Among authors: huang j. Nat Commun. 2018 Aug 14;9(1):3259. doi: 10.1038/s41467-018-05768-3. Nat Commun. 2018. PMID: 30108215 Free PMC article.
Fibroblast growth factor receptor 3 activates a network of profibrotic signaling pathways to promote fibrosis in systemic sclerosis.
Chakraborty D, Zhu H, Jüngel A, Summa L, Li YN, Matei AE, Zhou X, Huang J, Trinh-Minh T, Chen CW, Lafyatis R, Dees C, Bergmann C, Soare A, Luo H, Ramming A, Schett G, Distler O, Distler JHW. Chakraborty D, et al. Among authors: huang j. Sci Transl Med. 2020 Sep 30;12(563):eaaz5506. doi: 10.1126/scitranslmed.aaz5506. Sci Transl Med. 2020. PMID: 32998972
Inhibition of H3K27 histone trimethylation activates fibroblasts and induces fibrosis.
Krämer M, Dees C, Huang J, Schlottmann I, Palumbo-Zerr K, Zerr P, Gelse K, Beyer C, Distler A, Marquez VE, Distler O, Schett G, Distler JH. Krämer M, et al. Among authors: huang j. Ann Rheum Dis. 2013 Apr;72(4):614-20. doi: 10.1136/annrheumdis-2012-201615. Epub 2012 Aug 21. Ann Rheum Dis. 2013. PMID: 22915621
Vitamin D receptor regulates TGF-β signalling in systemic sclerosis.
Zerr P, Vollath S, Palumbo-Zerr K, Tomcik M, Huang J, Distler A, Beyer C, Dees C, Gela K, Distler O, Schett G, Distler JH. Zerr P, et al. Among authors: huang j. Ann Rheum Dis. 2015 Mar;74(3):e20. doi: 10.1136/annrheumdis-2013-204378. Epub 2014 Jan 21. Ann Rheum Dis. 2015. PMID: 24448349
53,743 results
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