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TGF-β1-mediated fibrosis and ion channel remodeling are key mechanisms in producing the sinus node dysfunction associated with SCN5A deficiency and aging.
Hao X, Zhang Y, Zhang X, Nirmalan M, Davies L, Konstantinou D, Yin F, Dobrzynski H, Wang X, Grace A, Zhang H, Boyett M, Huang CL, Lei M. Hao X, et al. Among authors: huang cl. Circ Arrhythm Electrophysiol. 2011 Jun;4(3):397-406. doi: 10.1161/CIRCEP.110.960807. Epub 2011 Apr 14. Circ Arrhythm Electrophysiol. 2011. PMID: 21493874
Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a.
Papadatos GA, Wallerstein PM, Head CE, Ratcliff R, Brady PA, Benndorf K, Saumarez RC, Trezise AE, Huang CL, Vandenberg JI, Colledge WH, Grace AA. Papadatos GA, et al. Among authors: huang cl. Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6210-5. doi: 10.1073/pnas.082121299. Epub 2002 Apr 23. Proc Natl Acad Sci U S A. 2002. PMID: 11972032 Free PMC article.
Impaired impulse propagation in Scn5a-knockout mice: combined contribution of excitability, connexin expression, and tissue architecture in relation to aging.
van Veen TA, Stein M, Royer A, Le Quang K, Charpentier F, Colledge WH, Huang CL, Wilders R, Grace AA, Escande D, de Bakker JM, van Rijen HV. van Veen TA, et al. Among authors: huang cl. Circulation. 2005 Sep 27;112(13):1927-35. doi: 10.1161/CIRCULATIONAHA.105.539072. Epub 2005 Sep 19. Circulation. 2005. PMID: 16172272
1,577 results