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BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice.
Cheung K, Lu G, Sharma R, Vincek A, Zhang R, Plotnikov AN, Zhang F, Zhang Q, Ju Y, Hu Y, Zhao L, Han X, Meslamani J, Xu F, Jaganathan A, Shen T, Zhu H, Rusinova E, Zeng L, Zhou J, Yang J, Peng L, Ohlmeyer M, Walsh MJ, Zhang DY, Xiong H, Zhou MM. Cheung K, et al. Among authors: hu y. Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):2952-2957. doi: 10.1073/pnas.1615601114. Epub 2017 Mar 6. Proc Natl Acad Sci U S A. 2017. PMID: 28265070 Free PMC article.
T follicular helper cells restricted by IRF8 contribute to T cell-mediated inflammation.
Zhang R, Qi CF, Hu Y, Shan Y, Hsieh YP, Xu F, Lu G, Dai J, Gupta M, Cui M, Peng L, Yang J, Xue Q, Chen-Liang R, Chen K, Zhang Y, Fung-Leung WP, Mora JR, Li L, Morse HC 3rd, Ozato K, Heeger PS, Xiong H. Zhang R, et al. Among authors: hu y. J Autoimmun. 2019 Jan;96:113-122. doi: 10.1016/j.jaut.2018.09.001. Epub 2018 Sep 19. J Autoimmun. 2019. PMID: 30241692 Free PMC article.
Ligation of CD180 contributes to endotoxic shock by regulating the accumulation and immunosuppressive activity of myeloid-derived suppressor cells through STAT3.
Dong G, Yao X, Yan F, Zhang H, Zhu Y, Yang Y, Shi H, Zhang J, Ning Z, Wang C, Cheng P, Hu Y, Ma Q, Dai J, Li Z, Li C, Ming J, Li X, Si C, Xiong H. Dong G, et al. Among authors: hu y. Biochim Biophys Acta Mol Basis Dis. 2019 Mar 1;1865(3):535-546. doi: 10.1016/j.bbadis.2018.12.013. Epub 2018 Dec 14. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 30557700 Free article.
HIPK2 directs cell type-specific regulation of STAT3 transcriptional activity in Th17 cell differentiation.
Cheung KL, Jaganathan A, Hu Y, Xu F, Lejeune A, Sharma R, Caescu CI, Meslamani J, Vincek A, Zhang F, Lee K, Zaware N, Qayum AA, Ren C, Kaplan MH, He JC, Xiong H, Zhou MM. Cheung KL, et al. Among authors: hu y. Proc Natl Acad Sci U S A. 2022 Apr 5;119(14):e2117112119. doi: 10.1073/pnas.2117112119. Epub 2022 Mar 28. Proc Natl Acad Sci U S A. 2022. PMID: 35344430 Free PMC article.
Autophagy regulates accumulation and functional activity of granulocytic myeloid-derived suppressor cells via STAT3 signaling in endotoxin shock.
Dong G, Si C, Zhang Q, Yan F, Li C, Zhang H, Ma Q, Dai J, Li Z, Shi H, Wang B, Zhang J, Ming J, Hu Y, Geng S, Zhang Y, Li L, Xiong H. Dong G, et al. Among authors: hu y. Biochim Biophys Acta Mol Basis Dis. 2017 Nov;1863(11):2796-2807. doi: 10.1016/j.bbadis.2017.08.005. Epub 2017 Aug 9. Biochim Biophys Acta Mol Basis Dis. 2017. PMID: 28802852 Free article.
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