Hsin CH - Search Results

1

Transition from Syringe to Autoinjector Based on Bridging Pharmacokinetics and Pharmacodynamics of the P2Y₁₂ Receptor Antagonist Selatogrel in Healthy Subjects.

Zenklusen I, Hsin CH, Schilling U, Kankam M, Krause A, Ufer M, Dingemanse J. Zenklusen I, et al. Among authors: hsin ch. Clin Pharmacokinet. 2022 May;61(5):687-695. doi: 10.1007/s40262-021-01097-9. Epub 2021 Dec 28. Clin Pharmacokinet. 2022. PMID: 34961905 Clinical Trial.

2

Influence of hepatic impairment on the pharmacokinetics and pharmacodynamics of the P2Y12 receptor antagonist selatogrel.

Schilling U, Hsin CH, Delahaye S, Krause A, Wuelfrath H, Halabi A, Dingemanse J. Schilling U, et al. Among authors: hsin ch. Clin Transl Sci. 2022 Aug;15(8):1906-1915. doi: 10.1111/cts.13298. Epub 2022 May 18. Clin Transl Sci. 2022. PMID: 35583936 Free PMC article.

3

First-in-human study with ACT-1014-6470, a novel oral complement factor 5a receptor 1 (C5aR1) antagonist, supported by pharmacokinetic predictions from animals to patients.

Ort M, Dingemanse J, Hsin CH, Richard M, Huehn E, Sabattini G, van de Wetering J, Kornberger R, van den Anker J, Kaufmann P. Ort M, et al. Among authors: hsin ch. Basic Clin Pharmacol Toxicol. 2022 Aug;131(2):114-128. doi: 10.1111/bcpt.13756. Epub 2022 Jun 8. Basic Clin Pharmacol Toxicol. 2022. PMID: 35596117 Free article. Clinical Trial.

4

Modeling time-delayed concentration-QT effects with ACT-1014-6470, a novel oral complement factor 5a receptor 1 (C5a₁ receptor) antagonist.

Anliker-Ort M, Hsin CH, Krause A, Pfister M, van den Anker J, Dingemanse J, Kaufmann P. Anliker-Ort M, et al. Among authors: hsin ch. Pharmacol Res Perspect. 2023 Aug;11(4):e01112. doi: 10.1002/prp2.1112. Pharmacol Res Perspect. 2023. PMID: 37470156 Free PMC article.

5

Pharmacokinetics, pharmacodynamics and safety of the novel C-X-C chemokine receptor 3 antagonist ACT-777991: Results from the first-in-human study in healthy adults.

Boof ML, Géhin M, Voors-Pette C, Hsin CH, Sippel V, Strasser DS, Dingemanse J. Boof ML, et al. Among authors: hsin ch. Br J Clin Pharmacol. 2024 Feb;90(2):588-599. doi: 10.1111/bcp.15914. Epub 2023 Nov 16. Br J Clin Pharmacol. 2024. PMID: 37752659 Clinical Trial.

6

Mind the Gap: Model-Based Switching from Selatogrel to Maintenance Therapy with Oral P2Y12 Receptor Antagonists.

Hsin CH, Dingemanse J, Henrich A, Bernaud C, Gehin M, Krause A. Hsin CH, et al. Biomolecules. 2023 Sep 8;13(9):1365. doi: 10.3390/biom13091365. Biomolecules. 2023. PMID: 37759765 Free PMC article.

7

A Physiologically Based Pharmacokinetic Model of Voriconazole Integrating Time-Dependent Inhibition of CYP3A4, Genetic Polymorphisms of CYP2C19 and Predictions of Drug-Drug Interactions.

Li X, Frechen S, Moj D, Lehr T, Taubert M, Hsin CH, Mikus G, Neuvonen PJ, Olkkola KT, Saari TI, Fuhr U. Li X, et al. Among authors: hsin ch. Clin Pharmacokinet. 2020 Jun;59(6):781-808. doi: 10.1007/s40262-019-00856-z. Clin Pharmacokinet. 2020. PMID: 31853755

8

A Clinical Drug-Drug Interaction Study Assessing a Novel Drug Transporter Phenotyping Cocktail With Adefovir, Sitagliptin, Metformin, Pitavastatin, and Digoxin.

Trueck C, Hsin CH, Scherf-Clavel O, Schaeffeler E, Lenssen R, Gazzaz M, Gersie M, Taubert M, Quasdorff M, Schwab M, Kinzig M, Sörgel F, Stoffel MS, Fuhr U. Trueck C, et al. Among authors: hsin ch. Clin Pharmacol Ther. 2019 Dec;106(6):1398-1407. doi: 10.1002/cpt.1564. Epub 2019 Aug 12. Clin Pharmacol Ther. 2019. PMID: 31247117

9

Drinking Ethanol Has Few Acute Effects on CYP2C9, CYP2C19, NAT2, and P-Glycoprotein Activities but Somewhat Inhibits CYP1A2, CYP2D6, and Intestinal CYP3A: So What?

Gazzaz M, Kinzig M, Schaeffeler E, Jübner M, Hsin CH, Li X, Taubert M, Trueck C, Iltgen-Breburda J, Kraus D, Queckenberg C, Stoffel M, Schwab M, Sörgel F, Fuhr U. Gazzaz M, et al. Among authors: hsin ch. Clin Pharmacol Ther. 2018 Dec;104(6):1249-1259. doi: 10.1002/cpt.1083. Epub 2018 May 10. Clin Pharmacol Ther. 2018. PMID: 29633238 Clinical Trial.

10

Response to "Impact of Acute Alcohol Exposure on P-Glycoprotein Function at the Blood-Brain Barrier Assessed Using ¹¹ C-Metoclopramide PET Imaging".

Hsin CH, Fuhr U, Trueck C. Hsin CH, et al. Clin Pharmacol Ther. 2019 Apr;105(4):814. doi: 10.1002/cpt.1265. Epub 2018 Dec 4. Clin Pharmacol Ther. 2019. PMID: 30515759 No abstract available.

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