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Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling.
Bosakova M, Abraham SP, Nita A, Hruba E, Buchtova M, Taylor SP, Duran I, Martin J, Svozilova K, Barta T, Varecha M, Balek L, Kohoutek J, Radaszkiewicz T, Pusapati GV, Bryja V, Rush ET, Thiffault I, Nickerson DA, Bamshad MJ; University of Washington Center for Mendelian Genomics; Rohatgi R, Cohn DH, Krakow D, Krejci P. Bosakova M, et al. Among authors: hruba e. EMBO Mol Med. 2020 Nov 6;12(11):e11739. doi: 10.15252/emmm.201911739. Epub 2020 Oct 14. EMBO Mol Med. 2020. PMID: 33200460 Free PMC article.
An RNA aptamer restores defective bone growth in FGFR3-related skeletal dysplasia in mice.
Kimura T, Bosakova M, Nonaka Y, Hruba E, Yasuda K, Futakawa S, Kubota T, Fafilek B, Gregor T, Abraham SP, Gomolkova R, Belaskova S, Pesl M, Csukasi F, Duran I, Fujiwara M, Kavkova M, Zikmund T, Kaiser J, Buchtova M, Krakow D, Nakamura Y, Ozono K, Krejci P. Kimura T, et al. Among authors: hruba e. Sci Transl Med. 2021 May 5;13(592):eaba4226. doi: 10.1126/scitranslmed.aba4226. Sci Transl Med. 2021. PMID: 33952673
One reporter for in-cell activity profiling of majority of protein kinase oncogenes.
Gudernova I, Foldynova-Trantirkova S, Ghannamova BE, Fafilek B, Varecha M, Balek L, Hruba E, Jonatova L, Jelinkova I, Kunova Bosakova M, Trantirek L, Mayer J, Krejci P. Gudernova I, et al. Among authors: hruba e. Elife. 2017 Feb 15;6:e21536. doi: 10.7554/eLife.21536. Elife. 2017. PMID: 28199182 Free PMC article.
TGF-β1 signaling plays a dominant role in the crosstalk between TGF-β1 and the aryl hydrocarbon receptor ligand in prostate epithelial cells.
Staršíchová A, Hrubá E, Slabáková E, Pernicová Z, Procházková J, Pěnčíková K, Seda V, Kabátková M, Vondráček J, Kozubík A, Machala M, Souček K. Staršíchová A, et al. Among authors: hruba e. Cell Signal. 2012 Aug;24(8):1665-76. doi: 10.1016/j.cellsig.2012.04.008. Epub 2012 Apr 25. Cell Signal. 2012. PMID: 22560882
Genotoxic polycyclic aromatic hydrocarbons fail to induce the p53-dependent DNA damage response, apoptosis or cell-cycle arrest in human prostate carcinoma LNCaP cells.
Hrubá E, Trilecová L, Marvanová S, Krcmár P, Vykopalová L, Milcová A, Líbalová H, Topinka J, Starsíchová A, Soucek K, Vondrácek J, Machala M. Hrubá E, et al. Toxicol Lett. 2010 Sep 1;197(3):227-35. doi: 10.1016/j.toxlet.2010.06.004. Epub 2010 Jun 11. Toxicol Lett. 2010. PMID: 20542099
AhR-mediated changes in global gene expression in rat liver progenitor cells.
Faust D, Vondráček J, Krčmář P, Smerdová L, Procházková J, Hrubá E, Hulinková P, Kaina B, Dietrich C, Machala M. Faust D, et al. Among authors: hruba e. Arch Toxicol. 2013 Apr;87(4):681-98. doi: 10.1007/s00204-012-0979-z. Epub 2012 Nov 30. Arch Toxicol. 2013. PMID: 23196670
34 results