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211 results

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BRCA1 mediates protein homeostasis through the ubiquitination of PERK and IRE1.
Hromas R, Srinivasan G, Yang M, Jaiswal A, Totterdale TA, Phillips L, Kirby A, Khodayari N, Brantley M, Williamson EA, Kong KY. Hromas R, et al. iScience. 2022 Nov 19;25(12):105626. doi: 10.1016/j.isci.2022.105626. eCollection 2022 Dec 22. iScience. 2022. PMID: 36471805 Free PMC article.
In Vitro Reconstitutive Base Excision Repair (BER) Assay.
Jaiswal AS, Williamson EA, Jaiswal AS, Kong K, Hromas RA. Jaiswal AS, et al. Among authors: hromas ra. Methods Mol Biol. 2023;2701:91-112. doi: 10.1007/978-1-0716-3373-1_6. Methods Mol Biol. 2023. PMID: 37574477
Cellular Responses to Widespread DNA Replication Stress.
Nickoloff JA, Jaiswal AS, Sharma N, Williamson EA, Tran MT, Arris D, Yang M, Hromas R. Nickoloff JA, et al. Among authors: hromas r. Int J Mol Sci. 2023 Nov 29;24(23):16903. doi: 10.3390/ijms242316903. Int J Mol Sci. 2023. PMID: 38069223 Free PMC article. Review.
Crucial roles of the BRCA1-BARD1 E3 ubiquitin ligase activity in homology-directed DNA repair.
Wang M, Li W, Tomimatsu N, Yu CH, Ji JH, Alejo S, Witus SR, Alimbetov D, Fitzgerald O, Wu B, Wang Q, Huang Y, Gan Y, Dong F, Kwon Y, Sareddy GR, Curiel TJ, Habib AA, Hromas R, Dos Santos Passos C, Yao T, Ivanov DN, Brzovic PS, Burma S, Klevit RE, Zhao W. Wang M, et al. Among authors: hromas r. Mol Cell. 2023 Oct 19;83(20):3679-3691.e8. doi: 10.1016/j.molcel.2023.09.015. Epub 2023 Oct 4. Mol Cell. 2023. PMID: 37797621
Co-targeting BCL-XL and MCL-1 with DT2216 and AZD8055 synergistically inhibit small-cell lung cancer growth without causing on-target toxicities in mice.
Khan S, Kellish P, Connis N, Thummuri D, Wiegand J, Zhang P, Zhang X, Budamagunta V, Hua N, Yang Y, De U, Jin L, Zhang W, Zheng G, Hromas R, Hann C, Zajac-Kaye M, Kaye FJ, Zhou D. Khan S, et al. Among authors: hromas r. Cell Death Discov. 2023 Jan 2;9(1):1. doi: 10.1038/s41420-022-01296-8. Cell Death Discov. 2023. PMID: 36588105 Free PMC article.
DNA binding and RAD51 engagement by the BRCA2 C-terminus orchestrate DNA repair and replication fork preservation.
Kwon Y, Rösner H, Zhao W, Selemenakis P, He Z, Kawale AS, Katz JN, Rogers CM, Neal FE, Badamchi Shabestari A, Petrosius V, Singh AK, Joel MZ, Lu L, Holloway SP, Burma S, Mukherjee B, Hromas R, Mazin A, Wiese C, Sørensen CS, Sung P. Kwon Y, et al. Among authors: hromas r. Nat Commun. 2023 Jan 26;14(1):432. doi: 10.1038/s41467-023-36211-x. Nat Commun. 2023. PMID: 36702902 Free PMC article.
211 results