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Bis-phenanthroline copper(II) phthalate complexes are potent in vitro antitumour agents with 'self-activating' metallo-nuclease and DNA binding properties.
Kellett A, O'Connor M, McCann M, McNamara M, Lynch P, Rosair G, McKee V, Creaven B, Walsh M, McClean S, Foltyn A, O'Shea D, Howe O, Devereux M. Kellett A, et al. Among authors: o shea d, o connor m, howe o. Dalton Trans. 2011 Feb 7;40(5):1024-7. doi: 10.1039/c0dt01607a. Epub 2010 Dec 16. Dalton Trans. 2011. PMID: 21165464
Copper(II) complexes of salicylic acid combining superoxide dismutase mimetic properties with DNA binding and cleaving capabilities display promising chemotherapeutic potential with fast acting in vitro cytotoxicity against cisplatin sensitive and resistant cancer cell lines.
O'Connor M, Kellett A, McCann M, Rosair G, McNamara M, Howe O, Creaven BS, McClean S, Kia AF, O'Shea D, Devereux M. O'Connor M, et al. Among authors: o shea d, howe o. J Med Chem. 2012 Mar 8;55(5):1957-68. doi: 10.1021/jm201041d. Epub 2012 Feb 28. J Med Chem. 2012. PMID: 22313179
Water-soluble and photo-stable silver(I) dicarboxylate complexes containing 1,10-phenanthroline ligands: Antimicrobial and anticancer chemotherapeutic potential, DNA interactions and antioxidant activity.
Thornton L, Dixit V, Assad LO, Ribeiro TP, Queiroz DD, Kellett A, Casey A, Colleran J, Pereira MD, Rochford G, McCann M, O'Shea D, Dempsey R, McClean S, Kia AF, Walsh M, Creaven B, Howe O, Devereux M. Thornton L, et al. Among authors: o shea d, howe o. J Inorg Biochem. 2016 Jun;159:120-32. doi: 10.1016/j.jinorgbio.2016.02.024. Epub 2016 Mar 2. J Inorg Biochem. 2016. PMID: 26986979
51 results