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Page 1
De novo design of luciferases using deep learning.
Yeh AH, Norn C, Kipnis Y, Tischer D, Pellock SJ, Evans D, Ma P, Lee GR, Zhang JZ, Anishchenko I, Coventry B, Cao L, Dauparas J, Halabiya S, DeWitt M, Carter L, Houk KN, Baker D. Yeh AH, et al. Among authors: houk kn. Nature. 2023 Feb;614(7949):774-780. doi: 10.1038/s41586-023-05696-3. Epub 2023 Feb 22. Nature. 2023. PMID: 36813896 Free PMC article.
De novo computational design of retro-aldol enzymes.
Jiang L, Althoff EA, Clemente FR, Doyle L, Röthlisberger D, Zanghellini A, Gallaher JL, Betker JL, Tanaka F, Barbas CF 3rd, Hilvert D, Houk KN, Stoddard BL, Baker D. Jiang L, et al. Among authors: houk kn. Science. 2008 Mar 7;319(5868):1387-91. doi: 10.1126/science.1152692. Science. 2008. PMID: 18323453 Free PMC article.
Kemp elimination catalysts by computational enzyme design.
Röthlisberger D, Khersonsky O, Wollacott AM, Jiang L, DeChancie J, Betker J, Gallaher JL, Althoff EA, Zanghellini A, Dym O, Albeck S, Houk KN, Tawfik DS, Baker D. Röthlisberger D, et al. Among authors: houk kn. Nature. 2008 May 8;453(7192):190-5. doi: 10.1038/nature06879. Epub 2008 Mar 19. Nature. 2008. PMID: 18354394
Evaluation and ranking of enzyme designs.
Kiss G, Röthlisberger D, Baker D, Houk KN. Kiss G, et al. Among authors: houk kn. Protein Sci. 2010 Sep;19(9):1760-73. doi: 10.1002/pro.462. Protein Sci. 2010. PMID: 20665693 Free PMC article.
Computational design of catalytic dyads and oxyanion holes for ester hydrolysis.
Richter F, Blomberg R, Khare SD, Kiss G, Kuzin AP, Smith AJ, Gallaher J, Pianowski Z, Helgeson RC, Grjasnow A, Xiao R, Seetharaman J, Su M, Vorobiev S, Lew S, Forouhar F, Kornhaber GJ, Hunt JF, Montelione GT, Tong L, Houk KN, Hilvert D, Baker D. Richter F, et al. Among authors: houk kn. J Am Chem Soc. 2012 Oct 3;134(39):16197-206. doi: 10.1021/ja3037367. Epub 2012 Sep 21. J Am Chem Soc. 2012. PMID: 22871159 Free PMC article.
Computational design of enone-binding proteins with catalytic activity for the Morita-Baylis-Hillman reaction.
Bjelic S, Nivón LG, Çelebi-Ölçüm N, Kiss G, Rosewall CF, Lovick HM, Ingalls EL, Gallaher JL, Seetharaman J, Lew S, Montelione GT, Hunt JF, Michael FE, Houk KN, Baker D. Bjelic S, et al. Among authors: houk kn. ACS Chem Biol. 2013 Apr 19;8(4):749-57. doi: 10.1021/cb3006227. Epub 2013 Jan 30. ACS Chem Biol. 2013. PMID: 23330600 Free PMC article.
Computational enzyme design.
Kiss G, Çelebi-Ölçüm N, Moretti R, Baker D, Houk KN. Kiss G, et al. Among authors: houk kn. Angew Chem Int Ed Engl. 2013 May 27;52(22):5700-25. doi: 10.1002/anie.201204077. Epub 2013 Mar 25. Angew Chem Int Ed Engl. 2013. PMID: 23526810 Review.
Substrate control in stereoselective lanthionine biosynthesis.
Tang W, Jiménez-Osés G, Houk KN, van der Donk WA. Tang W, et al. Among authors: houk kn. Nat Chem. 2015 Jan;7(1):57-64. doi: 10.1038/nchem.2113. Epub 2014 Nov 24. Nat Chem. 2015. PMID: 25515891 Free PMC article.
990 results