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Long-lived intestinal tuft cells serve as colon cancer-initiating cells.
Westphalen CB, Asfaha S, Hayakawa Y, Takemoto Y, Lukin DJ, Nuber AH, Brandtner A, Setlik W, Remotti H, Muley A, Chen X, May R, Houchen CW, Fox JG, Gershon MD, Quante M, Wang TC. Westphalen CB, et al. Among authors: houchen cw. J Clin Invest. 2014 Mar;124(3):1283-95. doi: 10.1172/JCI73434. J Clin Invest. 2014. PMID: 24487592 Free PMC article.
Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis.
Westphalen CB, Takemoto Y, Tanaka T, Macchini M, Jiang Z, Renz BW, Chen X, Ormanns S, Nagar K, Tailor Y, May R, Cho Y, Asfaha S, Worthley DL, Hayakawa Y, Urbanska AM, Quante M, Reichert M, Broyde J, Subramaniam PS, Remotti H, Su GH, Rustgi AK, Friedman RA, Honig B, Califano A, Houchen CW, Olive KP, Wang TC. Westphalen CB, et al. Among authors: houchen cw. Cell Stem Cell. 2016 Apr 7;18(4):441-55. doi: 10.1016/j.stem.2016.03.016. Cell Stem Cell. 2016. PMID: 27058937 Free PMC article.
XMD8-92 inhibits pancreatic tumor xenograft growth via a DCLK1-dependent mechanism.
Sureban SM, May R, Weygant N, Qu D, Chandrakesan P, Bannerman-Menson E, Ali N, Pantazis P, Westphalen CB, Wang TC, Houchen CW. Sureban SM, et al. Among authors: houchen cw. Cancer Lett. 2014 Aug 28;351(1):151-61. doi: 10.1016/j.canlet.2014.05.011. Epub 2014 May 28. Cancer Lett. 2014. PMID: 24880079
Inhibition of Notch signaling reduces the number of surviving Dclk1+ reserve crypt epithelial stem cells following radiation injury.
Qu D, May R, Sureban SM, Weygant N, Chandrakesan P, Ali N, Li L, Barrett T, Houchen CW. Qu D, et al. Among authors: houchen cw. Am J Physiol Gastrointest Liver Physiol. 2014 Mar 1;306(5):G404-11. doi: 10.1152/ajpgi.00088.2013. Epub 2013 Dec 24. Am J Physiol Gastrointest Liver Physiol. 2014. PMID: 24368703 Free PMC article.
Targeting pancreatitis blocks tumor-initiating stem cells and pancreatic cancer progression.
Mohammed A, Janakiram NB, Madka V, Brewer M, Ritchie RL, Lightfoot S, Kumar G, Sadeghi M, Patlolla JM, Yamada HY, Cruz-Monserrate Z, May R, Houchen CW, Steele VE, Rao CV. Mohammed A, et al. Among authors: houchen cw. Oncotarget. 2015 Jun 20;6(17):15524-39. doi: 10.18632/oncotarget.3499. Oncotarget. 2015. PMID: 25906749 Free PMC article.
125 results