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Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity.
Joas S, Parrish EH, Gnanadurai CW, Lump E, Stürzel CM, Parrish NF, Learn GH, Sauermann U, Neumann B, Rensing KM, Fuchs D, Billingsley JM, Bosinger SE, Silvestri G, Apetrei C, Huot N, Garcia-Tellez T, Müller-Trutwin M, Hotter D, Sauter D, Stahl-Hennig C, Hahn BH, Kirchhoff F. Joas S, et al. Among authors: hotter d. Nat Commun. 2018 Apr 10;9(1):1371. doi: 10.1038/s41467-018-03762-3. Nat Commun. 2018. PMID: 29636452 Free PMC article.
Differential regulation of NF-κB-mediated proviral and antiviral host gene expression by primate lentiviral Nef and Vpu proteins.
Sauter D, Hotter D, Van Driessche B, Stürzel CM, Kluge SF, Wildum S, Yu H, Baumann B, Wirth T, Plantier JC, Leoz M, Hahn BH, Van Lint C, Kirchhoff F. Sauter D, et al. Among authors: hotter d. Cell Rep. 2015 Feb 3;10(4):586-99. doi: 10.1016/j.celrep.2014.12.047. Epub 2015 Jan 22. Cell Rep. 2015. PMID: 25620704 Free PMC article.
Nef proteins of epidemic HIV-1 group O strains antagonize human tetherin.
Kluge SF, Mack K, Iyer SS, Pujol FM, Heigele A, Learn GH, Usmani SM, Sauter D, Joas S, Hotter D, Bibollet-Ruche F, Plenderleith LJ, Peeters M, Geyer M, Sharp PM, Fackler OT, Hahn BH, Kirchhoff F. Kluge SF, et al. Among authors: hotter d. Cell Host Microbe. 2014 Nov 12;16(5):639-50. doi: 10.1016/j.chom.2014.10.002. Epub 2014 Nov 12. Cell Host Microbe. 2014. PMID: 25525794 Free PMC article.
Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1.
Volcic M, Sparrer KMJ, Koepke L, Hotter D, Sauter D, Stürzel CM, Scherer M, Stamminger T, Hofmann TG, Arhel NJ, Wiesmüller L, Kirchhoff F. Volcic M, et al. Among authors: hotter d. Nat Microbiol. 2020 Oct;5(10):1247-1261. doi: 10.1038/s41564-020-0753-6. Epub 2020 Jul 20. Nat Microbiol. 2020. PMID: 32690953
28 results