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Characterization of imidazo[4,5-d]pyridazine nucleosides as modulators of unwinding reaction mediated by West Nile virus nucleoside triphosphatase/helicase: evidence for activity on the level of substrate and/or enzyme.
Borowski P, Lang M, Haag A, Schmitz H, Choe J, Chen HM, Hosmane RS. Borowski P, et al. Among authors: hosmane rs. Antimicrob Agents Chemother. 2002 May;46(5):1231-9. doi: 10.1128/AAC.46.5.1231-1239.2002. Antimicrob Agents Chemother. 2002. PMID: 11959550 Free PMC article.
Ring-expanded ("fat") nucleoside and nucleotide analogues exhibit potent in vitro activity against flaviviridae NTPases/helicases, including those of the West Nile virus, hepatitis C virus, and Japanese encephalitis virus.
Zhang N, Chen HM, Koch V, Schmitz H, Liao CL, Bretner M, Bhadti VS, Fattom AI, Naso RB, Hosmane RS, Borowski P. Zhang N, et al. Among authors: hosmane rs. J Med Chem. 2003 Sep 11;46(19):4149-64. doi: 10.1021/jm030842j. J Med Chem. 2003. PMID: 12954067
An analogue of AICAR with dual inhibitory activity against WNV and HCV NTPase/helicase: synthesis and in vitro screening of 4-carbamoyl-5-(4,6-diamino-2,5-dihydro-1,3,5-triazin-2-yl)imidazole-1-beta-D-ribofuranoside.
Ujjinamatada RK, Baier A, Borowski P, Hosmane RS. Ujjinamatada RK, et al. Among authors: hosmane rs. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2285-8. doi: 10.1016/j.bmcl.2007.01.074. Epub 2007 Jan 27. Bioorg Med Chem Lett. 2007. PMID: 17289387 Free PMC article.
A novel imidazole nucleoside containing a diaminodihydro-S-triazine as a substituent: inhibitory activity against the West Nile virus NTPase/helicase.
Ujjinamatada RK, Agasimundin YS, Zhang P, Hosmane RS, Schuessler R, Borowski P, Kalicharran K, Fattom A. Ujjinamatada RK, et al. Among authors: hosmane rs. Nucleosides Nucleotides Nucleic Acids. 2005;24(10-12):1775-88. doi: 10.1080/15257770500267063. Nucleosides Nucleotides Nucleic Acids. 2005. PMID: 16438047
Potent anti-hepatitis B viral activity and inhibition of bacteriophage T7 RNA polymerase by a "fat" nucleoside and its 5'-triphosphate derivative: synthetic, biochemical, and biological studies of 4,8-diamino-6-imino-6H-1-beta-D-ribofuranosyl-imidazo[4,5-E] [1,3]diazepine-5'-triphosphate.
Bretner M, Beckett D, Hosmane RS. Bretner M, et al. Among authors: hosmane rs. Nucleosides Nucleotides. 1999 Apr-May;18(4-5):837-8. doi: 10.1080/15257779908041574. Nucleosides Nucleotides. 1999. PMID: 10432689
57 results