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2,4-Diaminoquinazolines as Dual Toll-like Receptor (TLR) 7/8 Modulators for the Treatment of Hepatitis B Virus.
Embrechts W, Herschke F, Pauwels F, Stoops B, Last S, Pieters S, Pande V, Pille G, Amssoms K, Smyej I, Dhuyvetter D, Scholliers A, Mostmans W, Van Dijck K, Van Schoubroeck B, Thone T, De Pooter D, Fanning G, Jonckers THM, Horton H, Raboisson P, McGowan D. Embrechts W, et al. Among authors: horton h. J Med Chem. 2018 Jul 26;61(14):6236-6246. doi: 10.1021/acs.jmedchem.8b00643. Epub 2018 Jul 17. J Med Chem. 2018. PMID: 29965759
Identification and Optimization of Pyrrolo[3,2-d]pyrimidine Toll-like Receptor 7 (TLR7) Selective Agonists for the Treatment of Hepatitis B.
McGowan DC, Herschke F, Pauwels F, Stoops B, Smyej I, Last S, Pieters S, Embrechts W, Khamlichi MD, Thoné T, Van Schoubroeck B, Mostmans W, Wuyts D, Verstappen D, Scholliers A, De Pooter D, Dhuyvetter D, Borghys H, Tuefferd M, Arnoult E, Hong J, Fanning G, Bollekens J, Urmaliya V, Teisman A, Horton H, Jonckers THM, Raboisson P. McGowan DC, et al. Among authors: horton h. J Med Chem. 2017 Jul 27;60(14):6137-6151. doi: 10.1021/acs.jmedchem.7b00365. Epub 2017 Jul 14. J Med Chem. 2017. PMID: 28671847
Response of Human Liver Tissue to Innate Immune Stimuli.
Wu X, Roberto JB, Knupp A, Greninger AL, Truong CD, Hollingshead N, Kenerson HL, Tuefferd M, Chen A, Koelle DM, Horton H, Jerome KR, Polyak SJ, Yeung RS, Crispe IN. Wu X, et al. Among authors: horton h. Front Immunol. 2022 Mar 9;13:811551. doi: 10.3389/fimmu.2022.811551. eCollection 2022. Front Immunol. 2022. PMID: 35355993 Free PMC article.
Functional responses of resident human T cells in intact liver tissue.
Hollingshead N, Wu X, Kenerson H, Chen A, Strickland I, Horton H, Yeung R, Crispe IN. Hollingshead N, et al. Among authors: horton h. Cell Immunol. 2021 Feb;360:104275. doi: 10.1016/j.cellimm.2020.104275. Epub 2020 Dec 22. Cell Immunol. 2021. PMID: 33421676
Precision-cut human liver slice cultures as an immunological platform.
Wu X, Roberto JB, Knupp A, Kenerson HL, Truong CD, Yuen SY, Brempelis KJ, Tuefferd M, Chen A, Horton H, Yeung RS, Crispe IN. Wu X, et al. Among authors: horton h. J Immunol Methods. 2018 Apr;455:71-79. doi: 10.1016/j.jim.2018.01.012. Epub 2018 Feb 1. J Immunol Methods. 2018. PMID: 29408707 Free PMC article.
Human Liver Macrophage Subsets Defined by CD32.
Wu X, Hollingshead N, Roberto J, Knupp A, Kenerson H, Chen A, Strickland I, Horton H, Yeung R, Soysa R, Crispe IN. Wu X, et al. Among authors: horton h. Front Immunol. 2020 Sep 23;11:2108. doi: 10.3389/fimmu.2020.02108. eCollection 2020. Front Immunol. 2020. PMID: 33101269 Free PMC article.
226 results