Horn U - Search Results

1

Enhanced Fibril Fragmentation of N-Terminally Truncated and Pyroglutamyl-Modified Aβ Peptides.

Wulff M, Baumann M, Thümmler A, Yadav JK, Heinrich L, Knüpfer U, Schlenzig D, Schierhorn A, Rahfeld JU, Horn U, Balbach J, Demuth HU, Fändrich M. Wulff M, et al. Among authors: horn u. Angew Chem Int Ed Engl. 2016 Apr 11;55(16):5081-4. doi: 10.1002/anie.201511099. Epub 2016 Mar 11. Angew Chem Int Ed Engl. 2016. PMID: 26970534

2

Phosphate and HEPES buffers potently affect the fibrillation and oligomerization mechanism of Alzheimer's Aβ peptide.

Garvey M, Tepper K, Haupt C, Knüpfer U, Klement K, Meinhardt J, Horn U, Balbach J, Fändrich M. Garvey M, et al. Among authors: horn u. Biochem Biophys Res Commun. 2011 Jun 10;409(3):385-8. doi: 10.1016/j.bbrc.2011.04.141. Epub 2011 May 7. Biochem Biophys Res Commun. 2011. PMID: 21575606

3

Molecular basis of β-amyloid oligomer recognition with a conformational antibody fragment.

Morgado I, Wieligmann K, Bereza M, Rönicke R, Meinhardt K, Annamalai K, Baumann M, Wacker J, Hortschansky P, Malešević M, Parthier C, Mawrin C, Schiene-Fischer C, Reymann KG, Stubbs MT, Balbach J, Görlach M, Horn U, Fändrich M. Morgado I, et al. Among authors: horn u. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12503-8. doi: 10.1073/pnas.1206433109. Epub 2012 Jul 18. Proc Natl Acad Sci U S A. 2012. PMID: 22814377 Free PMC article.

4

Oligomer-targeting with a conformational antibody fragment promotes toxicity in Aβ-expressing flies.

Wacker J, Rönicke R, Westermann M, Wulff M, Reymann KG, Dobson CM, Horn U, Crowther DC, Luheshi LM, Fändrich M. Wacker J, et al. Among authors: horn u. Acta Neuropathol Commun. 2014 Apr 11;2:43. doi: 10.1186/2051-5960-2-43. Acta Neuropathol Commun. 2014. PMID: 24725347 Free PMC article.

5

Structure and biomedical applications of amyloid oligomer nanoparticles.

Kumar ST, Meinhardt J, Fuchs AK, Aumüller T, Leppert J, Büchele B, Knüpfer U, Ramachandran R, Yadav JK, Prell E, Morgado I, Ohlenschläger O, Horn U, Simmet T, Görlach M, Fändrich M. Kumar ST, et al. Among authors: horn u. ACS Nano. 2014 Nov 25;8(11):11042-52. doi: 10.1021/nn503960h. Epub 2014 Oct 22. ACS Nano. 2014. PMID: 25337989

6

Molecular architecture of Aβ fibrils grown in cerebrospinal fluid solution and in a cell culture model of Aβ plaque formation.

Garvey M, Baumann M, Wulff M, Kumar ST, Markx D, Morgado I, Knüpfer U, Horn U, Mawrin C, Fändrich M, Balbach J. Garvey M, et al. Among authors: horn u. Amyloid. 2016 Jun;23(2):76-85. doi: 10.3109/13506129.2016.1146989. Epub 2016 Mar 14. Amyloid. 2016. PMID: 26972581

7

Pattern recognition with a fibril-specific antibody fragment reveals the surface variability of natural amyloid fibrils.

Haupt C, Bereza M, Kumar ST, Kieninger B, Morgado I, Hortschansky P, Fritz G, Röcken C, Horn U, Fändrich M. Haupt C, et al. Among authors: horn u. J Mol Biol. 2011 May 6;408(3):529-40. doi: 10.1016/j.jmb.2011.02.032. Epub 2011 Mar 3. J Mol Biol. 2011. PMID: 21376731

8

Electron tomography reveals the fibril structure and lipid interactions in amyloid deposits.

Kollmer M, Meinhardt K, Haupt C, Liberta F, Wulff M, Linder J, Handl L, Heinrich L, Loos C, Schmidt M, Syrovets T, Simmet T, Westermark P, Westermark GT, Horn U, Schmidt V, Walther P, Fändrich M. Kollmer M, et al. Among authors: horn u. Proc Natl Acad Sci U S A. 2016 May 17;113(20):5604-9. doi: 10.1073/pnas.1523496113. Epub 2016 May 2. Proc Natl Acad Sci U S A. 2016. PMID: 27140609 Free PMC article.

9

Amyloid fibril recognition with the conformational B10 antibody fragment depends on electrostatic interactions.

Haupt C, Morgado I, Kumar ST, Parthier C, Bereza M, Hortschansky P, Stubbs MT, Horn U, Fändrich M. Haupt C, et al. Among authors: horn u. J Mol Biol. 2011 Jan 14;405(2):341-8. doi: 10.1016/j.jmb.2010.10.059. Epub 2010 Nov 6. J Mol Biol. 2011. PMID: 21059358

10

Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Abeta protofibrils.

Habicht G, Haupt C, Friedrich RP, Hortschansky P, Sachse C, Meinhardt J, Wieligmann K, Gellermann GP, Brodhun M, Götz J, Halbhuber KJ, Röcken C, Horn U, Fändrich M. Habicht G, et al. Among authors: horn u. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19232-7. doi: 10.1073/pnas.0703793104. Epub 2007 Nov 27. Proc Natl Acad Sci U S A. 2007. PMID: 18042730 Free PMC article.

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