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An atlas of substrate specificities for the human serine/threonine kinome.
Johnson JL, Yaron TM, Huntsman EM, Kerelsky A, Song J, Regev A, Lin TY, Liberatore K, Cizin DM, Cohen BM, Vasan N, Ma Y, Krismer K, Robles JT, van de Kooij B, van Vlimmeren AE, Andrée-Busch N, Käufer NF, Dorovkov MV, Ryazanov AG, Takagi Y, Kastenhuber ER, Goncalves MD, Hopkins BD, Elemento O, Taatjes DJ, Maucuer A, Yamashita A, Degterev A, Uduman M, Lu J, Landry SD, Zhang B, Cossentino I, Linding R, Blenis J, Hornbeck PV, Turk BE, Yaffe MB, Cantley LC. Johnson JL, et al. Among authors: hopkins bd. Nature. 2023 Jan;613(7945):759-766. doi: 10.1038/s41586-022-05575-3. Epub 2023 Jan 11. Nature. 2023. PMID: 36631611 Free PMC article.
Obesity and Cancer Mechanisms: Cancer Metabolism.
Hopkins BD, Goncalves MD, Cantley LC. Hopkins BD, et al. J Clin Oncol. 2016 Dec 10;34(35):4277-4283. doi: 10.1200/JCO.2016.67.9712. Epub 2016 Nov 7. J Clin Oncol. 2016. PMID: 27903152 Free PMC article. Review.
The PI3K Pathway in Human Disease.
Fruman DA, Chiu H, Hopkins BD, Bagrodia S, Cantley LC, Abraham RT. Fruman DA, et al. Among authors: hopkins bd. Cell. 2017 Aug 10;170(4):605-635. doi: 10.1016/j.cell.2017.07.029. Cell. 2017. PMID: 28802037 Free PMC article. Review.
Fenofibrate prevents skeletal muscle loss in mice with lung cancer.
Goncalves MD, Hwang SK, Pauli C, Murphy CJ, Cheng Z, Hopkins BD, Wu D, Loughran RM, Emerling BM, Zhang G, Fearon DT, Cantley LC. Goncalves MD, et al. Among authors: hopkins bd. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E743-E752. doi: 10.1073/pnas.1714703115. Epub 2018 Jan 8. Proc Natl Acad Sci U S A. 2018. PMID: 29311302 Free PMC article.
Cancer metabolism gets physical.
DelNero P, Hopkins BD, Cantley LC, Fischbach C. DelNero P, et al. Among authors: hopkins bd. Sci Transl Med. 2018 May 23;10(442):eaaq1011. doi: 10.1126/scitranslmed.aaq1011. Sci Transl Med. 2018. PMID: 29794058 Free PMC article. Review.
Suppression of insulin feedback enhances the efficacy of PI3K inhibitors.
Hopkins BD, Pauli C, Du X, Wang DG, Li X, Wu D, Amadiume SC, Goncalves MD, Hodakoski C, Lundquist MR, Bareja R, Ma Y, Harris EM, Sboner A, Beltran H, Rubin MA, Mukherjee S, Cantley LC. Hopkins BD, et al. Nature. 2018 Aug;560(7719):499-503. doi: 10.1038/s41586-018-0343-4. Epub 2018 Jul 4. Nature. 2018. PMID: 30051890 Free PMC article.
Phosphatidylinositol 3-Kinase, Growth Disorders, and Cancer.
Goncalves MD, Hopkins BD, Cantley LC. Goncalves MD, et al. Among authors: hopkins bd. N Engl J Med. 2018 Nov 22;379(21):2052-2062. doi: 10.1056/NEJMra1704560. N Engl J Med. 2018. PMID: 30462943 Review. No abstract available.
PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism.
Wang DG, Paddock MN, Lundquist MR, Sun JY, Mashadova O, Amadiume S, Bumpus TW, Hodakoski C, Hopkins BD, Fine M, Hill A, Yang TJ, Baskin JM, Dow LE, Cantley LC. Wang DG, et al. Among authors: hopkins bd. Cell Rep. 2019 May 14;27(7):1991-2001.e5. doi: 10.1016/j.celrep.2019.04.070. Cell Rep. 2019. PMID: 31091439 Free PMC article.
51 results