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Humanized tau antibodies promote tau uptake by human microglia without any increase of inflammation.
Zilkova M, Nolle A, Kovacech B, Kontsekova E, Weisova P, Filipcik P, Skrabana R, Prcina M, Hromadka T, Cehlar O, Rolkova GP, Maderova D, Novak M, Zilka N, Hoozemans JJM. Zilkova M, et al. Among authors: hoozemans jjm. Acta Neuropathol Commun. 2020 May 29;8(1):74. doi: 10.1186/s40478-020-00948-z. Acta Neuropathol Commun. 2020. PMID: 32471486 Free PMC article.
Ubiquilin 2 is not associated with tau pathology.
Nölle A, van Haastert ES, Zwart R, Hoozemans JJ, Scheper W. Nölle A, et al. PLoS One. 2013 Sep 26;8(9):e76598. doi: 10.1371/journal.pone.0076598. eCollection 2013. PLoS One. 2013. PMID: 24086754 Free PMC article.
Immunological memory to hyperphosphorylated tau in asymptomatic individuals.
Pascual G, Wadia JS, Zhu X, Keogh E, Kükrer B, van Ameijde J, Inganäs H, Siregar B, Perdok G, Diefenbach O, Nahar T, Sprengers I, Koldijk MH, der Linden EC, Peferoen LA, Zhang H, Yu W, Li X, Wagner M, Moreno V, Kim J, Costa M, West K, Fulton Z, Chammas L, Luckashenak N, Fletcher L, Holland T, Arnold C, Anthony Williamson R, Hoozemans JJ, Apetri A, Bard F, Wilson IA, Koudstaal W, Goudsmit J. Pascual G, et al. Acta Neuropathol. 2017 May;133(5):767-783. doi: 10.1007/s00401-017-1705-y. Epub 2017 Mar 24. Acta Neuropathol. 2017. PMID: 28341999 Free PMC article.
A common antigenic motif recognized by naturally occurring human VH5-51/VL4-1 anti-tau antibodies with distinct functionalities.
Apetri A, Crespo R, Juraszek J, Pascual G, Janson R, Zhu X, Zhang H, Keogh E, Holland T, Wadia J, Verveen H, Siregar B, Mrosek M, Taggenbrock R, Ameijde J, Inganäs H, van Winsen M, Koldijk MH, Zuijdgeest D, Borgers M, Dockx K, Stoop EJM, Yu W, Brinkman-van der Linden EC, Ummenthum K, van Kolen K, Mercken M, Steinbacher S, de Marco D, Hoozemans JJ, Wilson IA, Koudstaal W, Goudsmit J. Apetri A, et al. Acta Neuropathol Commun. 2018 May 31;6(1):43. doi: 10.1186/s40478-018-0543-z. Acta Neuropathol Commun. 2018. PMID: 29855358 Free PMC article.
Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser422 containing epitope on pathological tau.
van Ameijde J, Crespo R, Janson R, Juraszek J, Siregar B, Verveen H, Sprengers I, Nahar T, Hoozemans JJ, Steinbacher S, Willems R, Delbroek L, Borgers M, Dockx K, Van Kolen K, Mercken M, Pascual G, Koudstaal W, Apetri A. van Ameijde J, et al. Acta Neuropathol Commun. 2018 Jul 12;6(1):59. doi: 10.1186/s40478-018-0562-9. Acta Neuropathol Commun. 2018. PMID: 30001207 Free PMC article.
149 results