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Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist.
Willard FS, Douros JD, Gabe MB, Showalter AD, Wainscott DB, Suter TM, Capozzi ME, van der Velden WJ, Stutsman C, Cardona GR, Urva S, Emmerson PJ, Holst JJ, D'Alessio DA, Coghlan MP, Rosenkilde MM, Campbell JE, Sloop KW. Willard FS, et al. Among authors: holst jj. JCI Insight. 2020 Sep 3;5(17):e140532. doi: 10.1172/jci.insight.140532. JCI Insight. 2020. PMID: 32730231 Free PMC article.
GLP-1 in NIDDM.
Holst JJ. Holst JJ. Diabet Med. 1996 Sep;13(9 Suppl 6):S156-60. Diabet Med. 1996. PMID: 8894501 Review.
Discovery of amino acid variants in the human glucose-dependent insulinotropic polypeptide (GIP) receptor: the impact on the pancreatic beta cell responses and functional expression studies in Chinese hamster fibroblast cells.
Almind K, Ambye L, Urhammer SA, Hansen T, Echwald SM, Holst JJ, Gromada J, Thorens B, Pedersen O. Almind K, et al. Among authors: holst jj. Diabetologia. 1998 Oct;41(10):1194-8. doi: 10.1007/s001250051051. Diabetologia. 1998. PMID: 9794107
On the physiology of GIP and GLP-1.
Holst JJ. Holst JJ. Horm Metab Res. 2004 Nov-Dec;36(11-12):747-54. doi: 10.1055/s-2004-826158. Horm Metab Res. 2004. PMID: 15655703 Review.
1,735 results