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Vectorized Treg-depleting αCTLA-4 elicits antigen cross-presentation and CD8+ T cell immunity to reject 'cold' tumors.
J Immunother Cancer. 2022 Jan;10(1):e003488. doi: 10.1136/jitc-2021-003488.
J Immunother Cancer. 2022.
PMID: 35058324
Free PMC article.
Intestinal cDC1 drive cross-tolerance to epithelial-derived antigen via induction of FoxP3+CD8+ Tregs.
Joeris T, Gomez-Casado C, Holmkvist P, Tavernier SJ, Silva-Sanchez A, Klotz L, Randall TD, Mowat AM, Kotarsky K, Malissen B, Agace WW.
Joeris T, et al. Among authors: holmkvist p.
Sci Immunol. 2021 Jun 4;6(60):eabd3774. doi: 10.1126/sciimmunol.abd3774.
Sci Immunol. 2021.
PMID: 34088744
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IL-18Rα-deficient CD4(+) T cells induce intestinal inflammation in the CD45RB(hi) transfer model of colitis despite impaired innate responsiveness.
Holmkvist P, Pool L, Hägerbrand K, Agace WW, Rivollier A.
Holmkvist P, et al.
Eur J Immunol. 2016 Jun;46(6):1371-82. doi: 10.1002/eji.201545957. Epub 2016 May 6.
Eur J Immunol. 2016.
PMID: 27062602
Free article.
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A major population of mucosal memory CD4+ T cells, coexpressing IL-18Rα and DR3, display innate lymphocyte functionality.
Holmkvist P, Roepstorff K, Uronen-Hansson H, Sandén C, Gudjonsson S, Patschan O, Grip O, Marsal J, Schmidtchen A, Hornum L, Erjefält JS, Håkansson K, Agace WW.
Holmkvist P, et al.
Mucosal Immunol. 2015 May;8(3):545-58. doi: 10.1038/mi.2014.87. Epub 2014 Oct 1.
Mucosal Immunol. 2015.
PMID: 25269704
Free PMC article.
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