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Page 1
The uric acid crystal receptor Clec12A potentiates type I interferon responses.
Li K, Neumann K, Duhan V, Namineni S, Hansen AL, Wartewig T, Kurgyis Z, Holm CK, Heikenwalder M, Lang KS, Ruland J. Li K, et al. Among authors: holm ck. Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18544-18549. doi: 10.1073/pnas.1821351116. Epub 2019 Aug 26. Proc Natl Acad Sci U S A. 2019. PMID: 31451663 Free PMC article.
T cells detect intracellular DNA but fail to induce type I IFN responses: implications for restriction of HIV replication.
Berg RK, Rahbek SH, Kofod-Olsen E, Holm CK, Melchjorsen J, Jensen DG, Hansen AL, Jørgensen LB, Ostergaard L, Tolstrup M, Larsen CS, Paludan SR, Jakobsen MR, Mogensen TH. Berg RK, et al. Among authors: holm ck. PLoS One. 2014 Jan 3;9(1):e84513. doi: 10.1371/journal.pone.0084513. eCollection 2014. PLoS One. 2014. PMID: 24404168 Free PMC article.
An innate antiviral pathway acting before interferons at epithelial surfaces.
Iversen MB, Reinert LS, Thomsen MK, Bagdonaite I, Nandakumar R, Cheshenko N, Prabakaran T, Vakhrushev SY, Krzyzowska M, Kratholm SK, Ruiz-Perez F, Petersen SV, Goriely S, Bibby BM, Eriksson K, Ruland J, Thomsen AR, Herold BC, Wandall HH, Frische S, Holm CK, Paludan SR. Iversen MB, et al. Among authors: holm ck. Nat Immunol. 2016 Feb;17(2):150-8. doi: 10.1038/ni.3319. Epub 2015 Nov 30. Nat Immunol. 2016. PMID: 26595890
Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses.
Holm CK, Rahbek SH, Gad HH, Bak RO, Jakobsen MR, Jiang Z, Hansen AL, Jensen SK, Sun C, Thomsen MK, Laustsen A, Nielsen CG, Severinsen K, Xiong Y, Burdette DL, Hornung V, Lebbink RJ, Duch M, Fitzgerald KA, Bahrami S, Mikkelsen JG, Hartmann R, Paludan SR. Holm CK, et al. Nat Commun. 2016 Feb 19;7:10680. doi: 10.1038/ncomms10680. Nat Commun. 2016. PMID: 26893169 Free PMC article.
Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling.
Hansen AL, Buchan GJ, Rühl M, Mukai K, Salvatore SR, Ogawa E, Andersen SD, Iversen MB, Thielke AL, Gunderstofte C, Motwani M, Møller CT, Jakobsen AS, Fitzgerald KA, Roos J, Lin R, Maier TJ, Goldbach-Mansky R, Miner CA, Qian W, Miner JJ, Rigby RE, Rehwinkel J, Jakobsen MR, Arai H, Taguchi T, Schopfer FJ, Olagnier D, Holm CK. Hansen AL, et al. Among authors: holm ck. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7768-E7775. doi: 10.1073/pnas.1806239115. Epub 2018 Jul 30. Proc Natl Acad Sci U S A. 2018. PMID: 30061387 Free PMC article.
Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming.
Olagnier D, Brandtoft AM, Gunderstofte C, Villadsen NL, Krapp C, Thielke AL, Laustsen A, Peri S, Hansen AL, Bonefeld L, Thyrsted J, Bruun V, Iversen MB, Lin L, Artegoitia VM, Su C, Yang L, Lin R, Balachandran S, Luo Y, Nyegaard M, Marrero B, Goldbach-Mansky R, Motwani M, Ryan DG, Fitzgerald KA, O'Neill LA, Hollensen AK, Damgaard CK, de Paoli FV, Bertram HC, Jakobsen MR, Poulsen TB, Holm CK. Olagnier D, et al. Among authors: holm ck. Nat Commun. 2018 Aug 29;9(1):3506. doi: 10.1038/s41467-018-05861-7. Nat Commun. 2018. PMID: 30158636 Free PMC article.
STING palmitoylation as a therapeutic target.
Hansen AL, Mukai K, Schopfer FJ, Taguchi T, Holm CK. Hansen AL, et al. Among authors: holm ck. Cell Mol Immunol. 2019 Mar;16(3):236-241. doi: 10.1038/s41423-019-0205-5. Epub 2019 Feb 22. Cell Mol Immunol. 2019. PMID: 30796349 Free PMC article. Review.
SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate.
Olagnier D, Farahani E, Thyrsted J, Blay-Cadanet J, Herengt A, Idorn M, Hait A, Hernaez B, Knudsen A, Iversen MB, Schilling M, Jørgensen SE, Thomsen M, Reinert LS, Lappe M, Hoang HD, Gilchrist VH, Hansen AL, Ottosen R, Nielsen CG, Møller C, van der Horst D, Peri S, Balachandran S, Huang J, Jakobsen M, Svenningsen EB, Poulsen TB, Bartsch L, Thielke AL, Luo Y, Alain T, Rehwinkel J, Alcamí A, Hiscott J, Mogensen TH, Paludan SR, Holm CK. Olagnier D, et al. Among authors: holm ck. Nat Commun. 2020 Oct 2;11(1):4938. doi: 10.1038/s41467-020-18764-3. Nat Commun. 2020. PMID: 33009401 Free PMC article.
51 results