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Rapid response flow cytometric assay for the detection of antibody responses to SARS-CoV-2.
Lapuente D, Maier C, Irrgang P, Hübner J, Peter AS, Hoffmann M, Ensser A, Ziegler K, Winkler TH, Birkholz T, Kremer AE, Steininger P, Korn K, Neipel F, Überla K, Tenbusch M. Lapuente D, et al. Among authors: hoffmann m. Eur J Clin Microbiol Infect Dis. 2021 Apr;40(4):751-759. doi: 10.1007/s10096-020-04072-7. Epub 2020 Oct 20. Eur J Clin Microbiol Infect Dis. 2021. PMID: 33078221 Free PMC article.
Sphingosine prevents binding of SARS-CoV-2 spike to its cellular receptor ACE2.
Edwards MJ, Becker KA, Gripp B, Hoffmann M, Keitsch S, Wilker B, Soddemann M, Gulbins A, Carpinteiro E, Patel SH, Wilson GC, Pöhlmann S, Walter S, Fassbender K, Ahmad SA, Carpinteiro A, Gulbins E. Edwards MJ, et al. Among authors: hoffmann m. J Biol Chem. 2020 Nov 6;295(45):15174-15182. doi: 10.1074/jbc.RA120.015249. Epub 2020 Sep 11. J Biol Chem. 2020. PMID: 32917722 Free PMC article.
Low serum neutralizing anti-SARS-CoV-2 S antibody levels in mildly affected COVID-19 convalescent patients revealed by two different detection methods.
Bošnjak B, Stein SC, Willenzon S, Cordes AK, Puppe W, Bernhardt G, Ravens I, Ritter C, Schultze-Florey CR, Gödecke N, Martens J, Kleine-Weber H, Hoffmann M, Cossmann A, Yilmaz M, Pink I, Hoeper MM, Behrens GMN, Pöhlmann S, Blasczyk R, Schulz TF, Förster R. Bošnjak B, et al. Among authors: hoffmann m. Cell Mol Immunol. 2021 Apr;18(4):936-944. doi: 10.1038/s41423-020-00573-9. Epub 2020 Nov 2. Cell Mol Immunol. 2021. PMID: 33139905 Free PMC article.
Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells.
Carpinteiro A, Edwards MJ, Hoffmann M, Kochs G, Gripp B, Weigang S, Adams C, Carpinteiro E, Gulbins A, Keitsch S, Sehl C, Soddemann M, Wilker B, Kamler M, Bertsch T, Lang KS, Patel S, Wilson GC, Walter S, Hengel H, Pöhlmann S, Lang PA, Kornhuber J, Becker KA, Ahmad SA, Fassbender K, Gulbins E. Carpinteiro A, et al. Among authors: hoffmann m. Cell Rep Med. 2020 Nov 17;1(8):100142. doi: 10.1016/j.xcrm.2020.100142. Epub 2020 Oct 29. Cell Rep Med. 2020. PMID: 33163980 Free PMC article.
Mutation D614G increases SARS-CoV-2 transmission.
Arora P, Pöhlmann S, Hoffmann M. Arora P, et al. Among authors: hoffmann m. Signal Transduct Target Ther. 2021 Mar 1;6(1):101. doi: 10.1038/s41392-021-00502-w. Signal Transduct Target Ther. 2021. PMID: 33649299 Free PMC article. No abstract available.
Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection.
Wettstein L, Weil T, Conzelmann C, Müller JA, Groß R, Hirschenberger M, Seidel A, Klute S, Zech F, Prelli Bozzo C, Preising N, Fois G, Lochbaum R, Knaff PM, Mailänder V, Ständker L, Thal DR, Schumann C, Stenger S, Kleger A, Lochnit G, Mayer B, Ruiz-Blanco YB, Hoffmann M, Sparrer KMJ, Pöhlmann S, Sanchez-Garcia E, Kirchhoff F, Frick M, Münch J. Wettstein L, et al. Among authors: hoffmann m. Nat Commun. 2021 Mar 19;12(1):1726. doi: 10.1038/s41467-021-21972-0. Nat Commun. 2021. PMID: 33741941 Free PMC article.
SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies.
Hoffmann M, Arora P, Groß R, Seidel A, Hörnich BF, Hahn AS, Krüger N, Graichen L, Hofmann-Winkler H, Kempf A, Winkler MS, Schulz S, Jäck HM, Jahrsdörfer B, Schrezenmeier H, Müller M, Kleger A, Münch J, Pöhlmann S. Hoffmann M, et al. Cell. 2021 Apr 29;184(9):2384-2393.e12. doi: 10.1016/j.cell.2021.03.036. Epub 2021 Mar 20. Cell. 2021. PMID: 33794143 Free PMC article.
SARS-CoV-2 mutations acquired in mink reduce antibody-mediated neutralization.
Hoffmann M, Zhang L, Krüger N, Graichen L, Kleine-Weber H, Hofmann-Winkler H, Kempf A, Nessler S, Riggert J, Winkler MS, Schulz S, Jäck HM, Pöhlmann S. Hoffmann M, et al. Cell Rep. 2021 Apr 20;35(3):109017. doi: 10.1016/j.celrep.2021.109017. Epub 2021 Apr 3. Cell Rep. 2021. PMID: 33857422 Free PMC article.
3,522 results