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Using ChEMBL to Complement Schistosome Drug Discovery.
Padalino G, Coghlan A, Pagliuca G, Forde-Thomas JE, Berriman M, Hoffmann KF. Padalino G, et al. Among authors: hoffmann kf. Pharmaceutics. 2023 Apr 28;15(5):1359. doi: 10.3390/pharmaceutics15051359. Pharmaceutics. 2023. PMID: 37242601 Free PMC article.
Modified Hederagenin Derivatives Demonstrate Ex Vivo Anthelmintic Activity against Fasciola hepatica.
Chakroborty A, Pritchard DR, Bouillon ME, Cervi A, Kraehenbuehl R, Wild C, Fenn C, Holdsworth P, Capner C, Padalino G, Forde-Thomas JE, Payne J, Smith BG, Fisher M, Lahmann M, Baird MS, Hoffmann KF. Chakroborty A, et al. Among authors: hoffmann kf. Pharmaceutics. 2023 Jul 3;15(7):1869. doi: 10.3390/pharmaceutics15071869. Pharmaceutics. 2023. PMID: 37514055 Free PMC article.
Questing for homoleptic mononuclear manganese complexes with monodentate O-donor ligands.
Pérez-Bitrián A, Munárriz J, Krause KB, Schlögl J, Hoffmann KF, Sturm JS, Hadi AN, Teutloff C, Wiesner A, Limberg C, Riedel S. Pérez-Bitrián A, et al. Among authors: hoffmann kf. Chem Sci. 2024 Mar 5;15(15):5564-5572. doi: 10.1039/d4sc00543k. eCollection 2024 Apr 17. Chem Sci. 2024. PMID: 38638238 Free PMC article.
Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes.
Padalino G, Celatka CA, Rienhoff HY Jr, Kalin JH, Cole PA, Lassalle D, Forde-Thomas J, Chalmers IW, Brancale A, Grunau C, Hoffmann KF. Padalino G, et al. Among authors: hoffmann kf. Wellcome Open Res. 2023 Mar 30;8:146. doi: 10.12688/wellcomeopenres.18826.1. eCollection 2023. Wellcome Open Res. 2023. PMID: 37520936 Free PMC article.
Perspective on Schistosomiasis Drug Discovery: Highlights from a Schistosomiasis Drug Discovery Workshop at Wellcome Collection, London, September 2022.
Caldwell N, Afshar R, Baragaña B, Bustinduy AL, Caffrey CR, Collins JJ, Fusco D, Garba A, Gardner M, Gomes M, Hoffmann KF, Hsieh M, Lo NC, McNamara CW, Nono JK, Padalino G, Read KD, Roestenberg M, Spangenberg T, Specht S, Gilbert IH. Caldwell N, et al. Among authors: hoffmann kf. ACS Infect Dis. 2023 May 12;9(5):1046-1055. doi: 10.1021/acsinfecdis.3c00081. Epub 2023 Apr 21. ACS Infect Dis. 2023. PMID: 37083395 Free PMC article. Review.
Pulmonary inflammation promoted by type-2 dendritic cells is a feature of human and murine schistosomiasis.
Houlder EL, Costain AH, Nambuya I, Brown SL, Koopman JPR, Langenberg MCC, Janse JJ, Hoogerwerf MA, Ridley AJL, Forde-Thomas JE, Colombo SAP, Winkel BMF, Galdon AA, Hoffmann KF, Cook PC, Roestenberg M, Mpairwe H, MacDonald AS. Houlder EL, et al. Among authors: hoffmann kf. Nat Commun. 2023 Apr 3;14(1):1863. doi: 10.1038/s41467-023-37502-z. Nat Commun. 2023. PMID: 37012228 Free PMC article.
253 results