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Long-term culture of genome-stable bipotent stem cells from adult human liver.
Huch M, Gehart H, van Boxtel R, Hamer K, Blokzijl F, Verstegen MM, Ellis E, van Wenum M, Fuchs SA, de Ligt J, van de Wetering M, Sasaki N, Boers SJ, Kemperman H, de Jonge J, Ijzermans JN, Nieuwenhuis EE, Hoekstra R, Strom S, Vries RR, van der Laan LJ, Cuppen E, Clevers H. Huch M, et al. Among authors: hoekstra r. Cell. 2015 Jan 15;160(1-2):299-312. doi: 10.1016/j.cell.2014.11.050. Epub 2014 Dec 18. Cell. 2015. PMID: 25533785 Free PMC article.
Large-Scale Production of LGR5-Positive Bipotential Human Liver Stem Cells.
Schneeberger K, Sánchez-Romero N, Ye S, van Steenbeek FG, Oosterhoff LA, Pla Palacin I, Chen C, van Wolferen ME, van Tienderen G, Lieshout R, Colemonts-Vroninks H, Schene I, Hoekstra R, Verstegen MMA, van der Laan LJW, Penning LC, Fuchs SA, Clevers H, De Kock J, Baptista PM, Spee B. Schneeberger K, et al. Among authors: hoekstra r. Hepatology. 2020 Jul;72(1):257-270. doi: 10.1002/hep.31037. Epub 2020 Apr 8. Hepatology. 2020. PMID: 31715015 Free PMC article.
Oxygen drives hepatocyte differentiation and phenotype stability in liver cell lines.
van Wenum M, Adam AAA, van der Mark VA, Chang JC, Wildenberg ME, Hendriks EJ, Jongejan A, Moerland PD, van Gulik TM, Oude Elferink RP, Chamuleau RAFM, Hoekstra R. van Wenum M, et al. Among authors: hoekstra r. J Cell Commun Signal. 2018 Sep;12(3):575-588. doi: 10.1007/s12079-018-0456-4. Epub 2018 Feb 4. J Cell Commun Signal. 2018. PMID: 29399736 Free PMC article.
HepaRG-Progenitor Cell Derived Hepatocytes Cultured in Bioartificial Livers Are Protected from Healthy- and Acute Liver Failure-Plasma Induced Toxicity.
van Wenum M, Treskes P, Adam AAA, van der Mark VA, Jongejan A, Moerland PD, van Gulik TM, Oude Elferink RPJ, Chamuleau RAFM, Hoekstra R. van Wenum M, et al. Among authors: hoekstra r. Cell Physiol Biochem. 2018;48(5):2189-2204. doi: 10.1159/000492560. Epub 2018 Aug 15. Cell Physiol Biochem. 2018. PMID: 30110678 Free article.
AMC-Bio-Artificial Liver culturing enhances mitochondrial biogenesis in human liver cell lines: The role of oxygen, medium perfusion and 3D configuration.
Adam AAA, van Wenum M, van der Mark VA, Jongejan A, Moerland PD, Houtkooper RH, Wanders RJA, Oude Elferink RP, Chamuleau RAFM, Hoekstra R. Adam AAA, et al. Among authors: hoekstra r. Mitochondrion. 2018 Mar;39:30-42. doi: 10.1016/j.mito.2017.08.011. Epub 2017 Aug 24. Mitochondrion. 2018. PMID: 28844938
543 results