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Gain-of-Function RHOA Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer.
Zhang H, Schaefer A, Wang Y, Hodge RG, Blake DR, Diehl JN, Papageorge AG, Stachler MD, Liao J, Zhou J, Wu Z, Akarca FG, de Klerk LK, Derks S, Pierobon M, Hoadley KA, Wang TC, Church G, Wong KK, Petricoin EF, Cox AD, Lowy DR, Der CJ, Bass AJ. Zhang H, et al. Among authors: hodge rg. Cancer Discov. 2020 Feb;10(2):288-305. doi: 10.1158/2159-8290.CD-19-0811. Epub 2019 Nov 26. Cancer Discov. 2020. PMID: 31771969 Free PMC article.
Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer.
Hobbs GA, Baker NM, Miermont AM, Thurman RD, Pierobon M, Tran TH, Anderson AO, Waters AM, Diehl JN, Papke B, Hodge RG, Klomp JE, Goodwin CM, DeLiberty JM, Wang J, Ng RWS, Gautam P, Bryant KL, Esposito D, Campbell SL, Petricoin EF 3rd, Simanshu DK, Aguirre AJ, Wolpin BM, Wennerberg K, Rudloff U, Cox AD, Der CJ. Hobbs GA, et al. Among authors: hodge rg. Cancer Discov. 2020 Jan;10(1):104-123. doi: 10.1158/2159-8290.CD-19-1006. Epub 2019 Oct 24. Cancer Discov. 2020. PMID: 31649109 Free PMC article.
The KRAS-regulated kinome identifies WEE1 and ERK coinhibition as a potential therapeutic strategy in KRAS-mutant pancreatic cancer.
Diehl JN, Klomp JE, Snare KR, Hibshman PS, Blake DR, Kaiser ZD, Gilbert TSK, Baldelli E, Pierobon M, Papke B, Yang R, Hodge RG, Rashid NU, Petricoin EF 3rd, Herring LE, Graves LM, Cox AD, Der CJ. Diehl JN, et al. Among authors: hodge rg. J Biol Chem. 2021 Nov;297(5):101335. doi: 10.1016/j.jbc.2021.101335. Epub 2021 Oct 22. J Biol Chem. 2021. PMID: 34688654 Free PMC article.
RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling.
Schaefer A, Hodge RG, Zhang H, Hobbs GA, Dilly J, Huynh MV, Goodwin CM, Zhang F, Diehl JN, Pierobon M, Baldelli E, Javaid S, Guthrie K, Rashid NU, Petricoin EF, Cox AD, Hahn WC, Aguirre AJ, Bass AJ, Der CJ. Schaefer A, et al. Among authors: hodge rg. Sci Signal. 2023 Dec 19;16(816):eadg5289. doi: 10.1126/scisignal.adg5289. Epub 2023 Dec 19. Sci Signal. 2023. PMID: 38113333 Free PMC article.
Regulating Rho GTPases and their regulators.
Hodge RG, Ridley AJ. Hodge RG, et al. Nat Rev Mol Cell Biol. 2016 Aug;17(8):496-510. doi: 10.1038/nrm.2016.67. Epub 2016 Jun 15. Nat Rev Mol Cell Biol. 2016. PMID: 27301673 Review.
Regulation and functions of RhoU and RhoV.
Hodge RG, Ridley AJ. Hodge RG, et al. Small GTPases. 2020 Jan;11(1):8-15. doi: 10.1080/21541248.2017.1362495. Epub 2017 Nov 30. Small GTPases. 2020. PMID: 29189096 Free PMC article. Review.
RhoU forms homo-oligomers to regulate cellular responses.
Clayton NS, Hodge RG, Infante E, Alibhai D, Zhou F, Ridley AJ. Clayton NS, et al. Among authors: hodge rg. J Cell Sci. 2024 Jan 15;137(2):jcs261645. doi: 10.1242/jcs.261645. Epub 2024 Jan 30. J Cell Sci. 2024. PMID: 38180080 Free PMC article.
The bench press mark revisited.
Meholic AJ, Hodge RG, Hartshorne MF. Meholic AJ, et al. Among authors: hodge rg. Clin Nucl Med. 1998 May;23(5):325-6. doi: 10.1097/00003072-199805000-00015. Clin Nucl Med. 1998. PMID: 9596163 No abstract available.
14 results