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Early-life mitochondrial DNA damage results in lifelong deficits in energy production mediated by redox signaling in Caenorhabditis elegans.
Hershberger KA, Rooney JP, Turner EA, Donoghue LJ, Bodhicharla R, Maurer LL, Ryde IT, Kim JJ, Joglekar R, Hibshman JD, Smith LL, Bhatt DP, Ilkayeva OR, Hirschey MD, Meyer JN. Hershberger KA, et al. Among authors: hirschey md. Redox Biol. 2021 Jul;43:102000. doi: 10.1016/j.redox.2021.102000. Epub 2021 May 5. Redox Biol. 2021. PMID: 33993056 Free PMC article.
Lysine glutarylation is a protein posttranslational modification regulated by SIRT5.
Tan M, Peng C, Anderson KA, Chhoy P, Xie Z, Dai L, Park J, Chen Y, Huang H, Zhang Y, Ro J, Wagner GR, Green MF, Madsen AS, Schmiesing J, Peterson BS, Xu G, Ilkayeva OR, Muehlbauer MJ, Braulke T, Mühlhausen C, Backos DS, Olsen CA, McGuire PJ, Pletcher SD, Lombard DB, Hirschey MD, Zhao Y. Tan M, et al. Among authors: hirschey md. Cell Metab. 2014 Apr 1;19(4):605-17. doi: 10.1016/j.cmet.2014.03.014. Cell Metab. 2014. PMID: 24703693 Free PMC article.
Targeting sirtuins for the treatment of diabetes.
Huynh FK, Hershberger KA, Hirschey MD. Huynh FK, et al. Among authors: hirschey md. Diabetes Manag (Lond). 2013 May 1;3(3):245-257. doi: 10.2217/dmt.13.6. Diabetes Manag (Lond). 2013. PMID: 25067957 Free PMC article.
Phosphoproteomic profiling of human myocardial tissues distinguishes ischemic from non-ischemic end stage heart failure.
Schechter MA, Hsieh MK, Njoroge LW, Thompson JW, Soderblom EJ, Feger BJ, Troupes CD, Hershberger KA, Ilkayeva OR, Nagel WL, Landinez GP, Shah KM, Burns VA, Santacruz L, Hirschey MD, Foster MW, Milano CA, Moseley MA, Piacentino V 3rd, Bowles DE. Schechter MA, et al. Among authors: hirschey md. PLoS One. 2014 Aug 12;9(8):e104157. doi: 10.1371/journal.pone.0104157. eCollection 2014. PLoS One. 2014. PMID: 25117565 Free PMC article.
Mitochondria, energetics, epigenetics, and cellular responses to stress.
Shaughnessy DT, McAllister K, Worth L, Haugen AC, Meyer JN, Domann FE, Van Houten B, Mostoslavsky R, Bultman SJ, Baccarelli AA, Begley TJ, Sobol RW, Hirschey MD, Ideker T, Santos JH, Copeland WC, Tice RR, Balshaw DM, Tyson FL. Shaughnessy DT, et al. Among authors: hirschey md. Environ Health Perspect. 2014 Dec;122(12):1271-8. doi: 10.1289/ehp.1408418. Epub 2014 Aug 15. Environ Health Perspect. 2014. PMID: 25127496 Free PMC article. Review.
Long-chain Acylcarnitines Reduce Lung Function by Inhibiting Pulmonary Surfactant.
Otsubo C, Bharathi S, Uppala R, Ilkayeva OR, Wang D, McHugh K, Zou Y, Wang J, Alcorn JF, Zuo YY, Hirschey MD, Goetzman ES. Otsubo C, et al. Among authors: hirschey md. J Biol Chem. 2015 Sep 25;290(39):23897-904. doi: 10.1074/jbc.M115.655837. Epub 2015 Aug 3. J Biol Chem. 2015. PMID: 26240137 Free PMC article.
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