Hirsch AKH - Search Results

1

Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening.

Zhu D, Johannsen S, Masini T, Simonin C, Haupenthal J, Illarionov B, Andreas A, Awale M, Gierse RM, van der Laan T, van der Vlag R, Nasti R, Poizat M, Buhler E, Reiling N, Müller R, Fischer M, Reymond JL, Hirsch AKH. Zhu D, et al. Among authors: hirsch akh. Chem Sci. 2022 Aug 8;13(36):10686-10698. doi: 10.1039/d2sc02371g. eCollection 2022 Sep 21. Chem Sci. 2022. PMID: 36320685 Free PMC article.

2

Biodynamers: self-organization-driven formation of doubly dynamic proteoids.

Hirsch AK, Buhler E, Lehn JM. Hirsch AK, et al. J Am Chem Soc. 2012 Mar 7;134(9):4177-83. doi: 10.1021/ja2099134. Epub 2012 Feb 21. J Am Chem Soc. 2012. PMID: 22300496

3

Druggability of the enzymes of the non-mevalonate-pathway.

Masini T, Kroezen BS, Hirsch AK. Masini T, et al. Drug Discov Today. 2013 Dec;18(23-24):1256-62. doi: 10.1016/j.drudis.2013.07.003. Epub 2013 Jul 13. Drug Discov Today. 2013. PMID: 23856326 Review.

4

Development of inhibitors of the 2C-methyl-D-erythritol 4-phosphate (MEP) pathway enzymes as potential anti-infective agents.

Masini T, Hirsch AK. Masini T, et al. J Med Chem. 2014 Dec 11;57(23):9740-63. doi: 10.1021/jm5010978. Epub 2014 Sep 25. J Med Chem. 2014. PMID: 25210872 Review.

5

Validation of a homology model of Mycobacterium tuberculosis DXS: rationalization of observed activities of thiamine derivatives as potent inhibitors of two orthologues of DXS.

Masini T, Lacy B, Monjas L, Hawksley D, de Voogd AR, Illarionov B, Iqbal A, Leeper FJ, Fischer M, Kontoyianni M, Hirsch AK. Masini T, et al. Org Biomol Chem. 2015 Dec 14;13(46):11263-77. doi: 10.1039/c5ob01666e. Epub 2015 Sep 28. Org Biomol Chem. 2015. PMID: 26411373

6

Fine-tuning Nanocarriers Specifically toward Cargo: A Competitive Study on Solubilizing Related Photosensitizers for Photodynamic Therapy.

Wieczorek S, Remmler D, Masini T, Kochovski Z, Hirsch AK, Börner HG. Wieczorek S, et al. Bioconjug Chem. 2017 Mar 15;28(3):760-767. doi: 10.1021/acs.bioconjchem.6b00549. Epub 2017 Jan 13. Bioconjug Chem. 2017. PMID: 28002941

7

Compounds Interfering with Embryonic Lethal Abnormal Vision (ELAV) Protein-RNA Complexes: An Avenue for Discovering New Drugs.

Nasti R, Rossi D, Amadio M, Pascale A, Unver MY, Hirsch AKH, Collina S. Nasti R, et al. Among authors: hirsch akh. J Med Chem. 2017 Oct 26;60(20):8257-8267. doi: 10.1021/acs.jmedchem.6b01871. Epub 2017 Jun 19. J Med Chem. 2017. PMID: 28587461

8

DXS as a target for structure-based drug design.

Gierse RM, Redeem E, Diamanti E, Wrenger C, Groves MR, Hirsch AK. Gierse RM, et al. Future Med Chem. 2017 Jul;9(11):1277-1294. doi: 10.4155/fmc-2016-0239. Epub 2017 Jun 21. Future Med Chem. 2017. PMID: 28636418 Review.

9

Saccharide-Containing Dynamic Proteoids.

Liu Y, Stuart MCA, Witte MD, Buhler E, Hirsch AKH. Liu Y, et al. Among authors: hirsch akh. Chemistry. 2017 Nov 16;23(64):16162-16166. doi: 10.1002/chem.201703584. Epub 2017 Oct 25. Chemistry. 2017. PMID: 28981987 Free PMC article.

10

Phage Display on the Anti-infective Target 1-Deoxy-d-xylulose-5-phosphate Synthase Leads to an Acceptor-Substrate Competitive Peptidic Inhibitor.

Marcozzi A, Masini T, Zhu D, Pesce D, Illarionov B, Fischer M, Herrmann A, Hirsch AKH. Marcozzi A, et al. Among authors: hirsch akh. Chembiochem. 2018 Jan 4;19(1):58-65. doi: 10.1002/cbic.201700402. Epub 2017 Dec 11. Chembiochem. 2018. PMID: 29119720 Free PMC article.

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