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CDK4/6-MEK Inhibition in MPNSTs Causes Plasma Cell Infiltration, Sensitization to PD-L1 Blockade, and Tumor Regression.
Kohlmeyer JL, Lingo JJ, Kaemmer CA, Scherer A, Warrier A, Voigt E, Raygoza Garay JA, McGivney GR, Brockman QR, Tang A, Calizo A, Pollard K, Zhang X, Hirbe AC, Pratilas CA, Leidinger M, Breheny P, Chimenti MS, Sieren JC, Monga V, Tanas MR, Meyerholz DK, Darbro BW, Dodd RD, Quelle DE. Kohlmeyer JL, et al. Among authors: hirbe ac. Clin Cancer Res. 2023 Sep 1;29(17):3484-3497. doi: 10.1158/1078-0432.CCR-23-0749. Clin Cancer Res. 2023. PMID: 37410426 Free PMC article.
Whole Exome Sequencing Reveals the Order of Genetic Changes during Malignant Transformation and Metastasis in a Single Patient with NF1-plexiform Neurofibroma.
Hirbe AC, Dahiya S, Miller CA, Li T, Fulton RS, Zhang X, McDonald S, DeSchryver K, Duncavage EJ, Walrath J, Reilly KM, Abel HJ, Pekmezci M, Perry A, Ley TJ, Gutmann DH. Hirbe AC, et al. Clin Cancer Res. 2015 Sep 15;21(18):4201-11. doi: 10.1158/1078-0432.CCR-14-3049. Epub 2015 Apr 29. Clin Cancer Res. 2015. PMID: 25925892 Free PMC article.
Chromosome 8 gain is associated with high-grade transformation in MPNST.
Dehner C, Moon CI, Zhang X, Zhou Z, Miller C, Xu H, Wan X, Yang K, Mashl J, Gosline SJ, Wang Y, Zhang X, Godec A, Jones PA, Dahiya S, Bhatia H, Primeau T, Li S, Pollard K, Rodriguez FJ, Ding L, Pratilas CA, Shern JF, Hirbe AC. Dehner C, et al. Among authors: hirbe ac. JCI Insight. 2021 Mar 22;6(6):e146351. doi: 10.1172/jci.insight.146351. JCI Insight. 2021. PMID: 33591953 Free PMC article.
Phase II study of pazopanib with oral topotecan in patients with metastatic and non-resectable soft tissue and bone sarcomas.
Schulte B, Mohindra N, Milhem M, Attia S, Robinson S, Monga V, Hirbe AC, Oppelt P, Charlson J, Helenowski I, Abbinanti S, Cehic R, Okuno S, Van Tine BA, Agulnik M. Schulte B, et al. Among authors: hirbe ac. Br J Cancer. 2021 Aug;125(4):528-533. doi: 10.1038/s41416-021-01448-0. Epub 2021 May 28. Br J Cancer. 2021. PMID: 34050255 Free PMC article. Clinical Trial.
An open-label single-arm phase II study of regorafenib for the treatment of angiosarcoma.
Agulnik M, Schulte B, Robinson S, Hirbe AC, Kozak K, Chawla SP, Attia S, Rademaker A, Zhang H, Abbinanti S, Cehic R, Monga V, Milhem M, Okuno S, Van Tine BA. Agulnik M, et al. Among authors: hirbe ac. Eur J Cancer. 2021 Sep;154:201-208. doi: 10.1016/j.ejca.2021.06.027. Epub 2021 Jul 17. Eur J Cancer. 2021. PMID: 34284255 Clinical Trial.
83 results