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CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory.
Kidani Y, Nogami W, Yasumizu Y, Kawashima A, Tanaka A, Sonoda Y, Tona Y, Nashiki K, Matsumoto R, Hagiwara M, Osaki M, Dohi K, Kanazawa T, Ueyama A, Yoshikawa M, Yoshida T, Matsumoto M, Hojo K, Shinonome S, Yoshida H, Hirata M, Haruna M, Nakamura Y, Motooka D, Okuzaki D, Sugiyama Y, Kinoshita M, Okuno T, Kato T, Hatano K, Uemura M, Imamura R, Yokoi K, Tanemura A, Shintani Y, Kimura T, Nonomura N, Wada H, Mori M, Doki Y, Ohkura N, Sakaguchi S. Kidani Y, et al. Among authors: hirata m. Proc Natl Acad Sci U S A. 2022 Feb 15;119(7):e2114282119. doi: 10.1073/pnas.2114282119. Proc Natl Acad Sci U S A. 2022. PMID: 35140181 Free PMC article.
Preclinical antitumor activity of S-222611, an oral reversible tyrosine kinase inhibitor of epidermal growth factor receptor and human epidermal growth factor receptor 2.
Tanaka H, Hirata M, Shinonome S, Wada T, Iguchi M, Dohi K, Inoue M, Ishioka Y, Hojo K, Yamada T, Sugimoto T, Masuno K, Nezasa K, Sato N, Matsuo K, Yonezawa S, Frenkel EP, Shichijo M. Tanaka H, et al. Among authors: hirata m. Cancer Sci. 2014 Aug;105(8):1040-8. doi: 10.1111/cas.12449. Cancer Sci. 2014. PMID: 24837299 Free PMC article.
Peri-operative monocyte count is a marker of poor prognosis in gastric cancer: increased monocytes are a characteristic of myeloid-derived suppressor cells.
Urakawa S, Yamasaki M, Goto K, Haruna M, Hirata M, Morimoto-Okazawa A, Kawashima A, Iwahori K, Makino T, Kurokawa Y, Yamada T, Mori M, Doki Y, Wada H. Urakawa S, et al. Among authors: hirata m. Cancer Immunol Immunother. 2019 Aug;68(8):1341-1350. doi: 10.1007/s00262-019-02366-0. Epub 2019 Jul 19. Cancer Immunol Immunother. 2019. PMID: 31324947 Free PMC article.
Endogenous CXCL9 affects prognosis by regulating tumor-infiltrating natural killer cells in intrahepatic cholangiocarcinoma.
Fukuda Y, Asaoka T, Eguchi H, Yokota Y, Kubo M, Kinoshita M, Urakawa S, Iwagami Y, Tomimaru Y, Akita H, Noda T, Gotoh K, Kobayashi S, Hirata M, Wada H, Mori M, Doki Y. Fukuda Y, et al. Among authors: hirata m. Cancer Sci. 2020 Feb;111(2):323-333. doi: 10.1111/cas.14267. Epub 2020 Jan 23. Cancer Sci. 2020. PMID: 31799781 Free PMC article.
Clinical importance of the expression of CD4+CD8+ T cells in renal cell carcinoma.
Nishida K, Kawashima A, Kanazawa T, Kidani Y, Yoshida T, Hirata M, Yamamoto K, Yamamoto Y, Sawada M, Kato R, Kato T, Hatano K, Ujike T, Fujita K, Uemura M, Morimoto-Okazawa A, Iwahori K, Yamasaki M, Ohkura N, Sakaguchi S, Nonomura N, Doki Y, Wada H. Nishida K, et al. Among authors: hirata m. Int Immunol. 2020 May 8;32(5):347-357. doi: 10.1093/intimm/dxaa004. Int Immunol. 2020. PMID: 31950169
PD-1+ Tim3+ tumor-infiltrating CD8 T cells sustain the potential for IFN-γ production, but lose cytotoxic activity in ovarian cancer.
Sawada M, Goto K, Morimoto-Okazawa A, Haruna M, Yamamoto K, Yamamoto Y, Nakagawa S, Hiramatsu K, Matsuzaki S, Kobayashi E, Kawashima A, Hirata M, Iwahori K, Kimura T, Ueda Y, Kimura T, Wada H. Sawada M, et al. Among authors: hirata m. Int Immunol. 2020 May 30;32(6):397-405. doi: 10.1093/intimm/dxaa010. Int Immunol. 2020. PMID: 32009163
Docetaxel Upregulates HMGB1 Levels in Non-small Cell Lung Cancer.
Haruna M, Hirata M, Iwahori K, Kanazawa T, Yamamoto Y, Goto K, Kawashima A, Morimoto-Okazawa A, Funaki S, Shintani Y, Kumanogoh A, Wada H. Haruna M, et al. Among authors: hirata m. Biol Pharm Bull. 2020;43(3):399-403. doi: 10.1248/bpb.b19-00702. Biol Pharm Bull. 2020. PMID: 32115500 Free article.
2,267 results