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Targeting cis-regulatory elements of FOXO family is a novel therapeutic strategy for induction of leukemia cell differentiation.
Kurayoshi K, Takase Y, Ueno M, Ohta K, Fuse K, Ikeda S, Watanabe T, Nishida Y, Horike SI, Hosomichi K, Ishikawa Y, Tadokoro Y, Kobayashi M, Kasahara A, Jing Y, Shoulkamy MI, Meguro-Horike M, Kojima K, Kiyoi H, Sugiyama H, Nagase H, Tajima A, Hirao A. Kurayoshi K, et al. Among authors: hirao a. Cell Death Dis. 2023 Sep 29;14(9):642. doi: 10.1038/s41419-023-06168-2. Cell Death Dis. 2023. PMID: 37773170 Free PMC article.
NKX2.2 suppresses self-renewal of glioma-initiating cells.
Muraguchi T, Tanaka S, Yamada D, Tamase A, Nakada M, Nakamura H, Hoshii T, Ooshio T, Tadokoro Y, Naka K, Ino Y, Todo T, Kuratsu J, Saya H, Hamada J, Hirao A. Muraguchi T, et al. Among authors: hirao a. Cancer Res. 2011 Feb 1;71(3):1135-45. doi: 10.1158/0008-5472.CAN-10-2304. Epub 2010 Dec 17. Cancer Res. 2011. PMID: 21169405
mTORC1 is essential for leukemia propagation but not stem cell self-renewal.
Hoshii T, Tadokoro Y, Naka K, Ooshio T, Muraguchi T, Sugiyama N, Soga T, Araki K, Yamamura K, Hirao A. Hoshii T, et al. Among authors: hirao a. J Clin Invest. 2012 Jun;122(6):2114-29. doi: 10.1172/JCI62279. Epub 2012 May 24. J Clin Invest. 2012. PMID: 22622041 Free PMC article.
Nucleostemin in injury-induced liver regeneration.
Shugo H, Ooshio T, Naito M, Naka K, Hoshii T, Tadokoro Y, Muraguchi T, Tamase A, Uema N, Yamashita T, Nakamoto Y, Suda T, Kaneko S, Hirao A. Shugo H, et al. Among authors: hirao a. Stem Cells Dev. 2012 Nov 1;21(16):3044-54. doi: 10.1089/scd.2011.0725. Epub 2012 Jul 9. Stem Cells Dev. 2012. PMID: 22775537
Loss of mTOR complex 1 induces developmental blockage in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells.
Hoshii T, Kasada A, Hatakeyama T, Ohtani M, Tadokoro Y, Naka K, Ikenoue T, Ikawa T, Kawamoto H, Fehling HJ, Araki K, Yamamura K, Matsuda S, Hirao A. Hoshii T, et al. Among authors: hirao a. Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3805-10. doi: 10.1073/pnas.1320265111. Epub 2014 Feb 24. Proc Natl Acad Sci U S A. 2014. PMID: 24567410 Free PMC article.
Association of a murine leukaemia stem cell gene signature based on nucleostemin promoter activity with prognosis of acute myeloid leukaemia in patients.
Ali MA, Naka K, Yoshida A, Fuse K, Kasada A, Hoshii T, Tadokoro Y, Ueno M, Ohta K, Kobayashi M, Takahashi C, Hirao A. Ali MA, et al. Among authors: hirao a. Biochem Biophys Res Commun. 2014 Jul 18;450(1):837-43. doi: 10.1016/j.bbrc.2014.06.066. Epub 2014 Jun 21. Biochem Biophys Res Commun. 2014. PMID: 24960197
279 results