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Population pharmacokinetic modeling of treosulfan and rationale for dose recommendation in children treated for conditioning prior to allogeneic hematopoietic stem cell transplantation.
Li X, Kalwak K, Beier R, Kehne J, Möller AK, Baumgart J, Beelen DW, Hilger RA, Vora A, Sykora KW. Li X, et al. Among authors: hilger ra. Drug Metab Pharmacokinet. 2023 Oct;52:100515. doi: 10.1016/j.dmpk.2023.100515. Epub 2023 May 30. Drug Metab Pharmacokinet. 2023. PMID: 37481830 Free article.
SAM-Competitive EZH2-Inhibitors Induce Platinum Resistance by EZH2-Independent Induction of ABC-Transporters.
Groß E, Hilger RA, Schümann FL, Bauer M, Bouska A, Rohde C, Willscher E, Lützkendorf J, Müller LP, Edemir B, Mueller T, Herling M, Binder M, Wickenhauser C, Iqbal J, Posern G, Weber T. Groß E, et al. Among authors: hilger ra. Cancers (Basel). 2023 Jun 3;15(11):3043. doi: 10.3390/cancers15113043. Cancers (Basel). 2023. PMID: 37297005 Free PMC article.
Diphenhydramine increases the therapeutic window for platinum drugs by simultaneously sensitizing tumor cells and protecting normal cells.
Melnikova M, Wauer US, Mendus D, Hilger RA, Oliver TG, Mercer K, Gohlke BO, Erdmann K, Niederacher D, Neubauer H, Buderath P, Wimberger P, Kuhlmann JD, Thomale J. Melnikova M, et al. Among authors: hilger ra. Mol Oncol. 2020 Apr;14(4):686-703. doi: 10.1002/1878-0261.12648. Epub 2020 Mar 10. Mol Oncol. 2020. PMID: 32037720 Free PMC article.
Treosulfan, Fludarabine, and Low-Dose Total Body Irradiation for Children and Young Adults with Acute Myeloid Leukemia or Myelodysplastic Syndrome Undergoing Allogeneic Hematopoietic Cell Transplantation: Prospective Phase II Trial of the Pediatric Blood and Marrow Transplant Consortium.
Nemecek ER, Hilger RA, Adams A, Shaw BE, Kiefer D, Le-Rademacher J, Levine JE, Yanik G, Leung W, Talano JA, Haut P, Delgado D, Kapoor N, Petrovic A, Adams R, Hanna R, Rangarajan H, Dalal J, Chewning J, Verneris MR, Epstein S, Burroughs L, Perez-Albuerne ED, Pulsipher MA, Delaney C. Nemecek ER, et al. Among authors: hilger ra. Biol Blood Marrow Transplant. 2018 Aug;24(8):1651-1656. doi: 10.1016/j.bbmt.2018.04.025. Epub 2018 May 9. Biol Blood Marrow Transplant. 2018. PMID: 29753157 Free PMC article. Clinical Trial.
Open-label, randomized study of individualized, pharmacokinetically (PK)-guided dosing of paclitaxel combined with carboplatin or cisplatin in patients with advanced non-small-cell lung cancer (NSCLC).
Joerger M, von Pawel J, Kraff S, Fischer JR, Eberhardt W, Gauler TC, Mueller L, Reinmuth N, Reck M, Kimmich M, Mayer F, Kopp HG, Behringer DM, Ko YD, Hilger RA, Roessler M, Kloft C, Henrich A, Moritz B, Miller MC, Salamone SJ, Jaehde U. Joerger M, et al. Among authors: hilger ra. Ann Oncol. 2016 Oct;27(10):1895-902. doi: 10.1093/annonc/mdw290. Epub 2016 Aug 8. Ann Oncol. 2016. PMID: 27502710 Free article. Clinical Trial.
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