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Aberrant TIMP-1 production in tumor-associated fibroblasts drives the selective benefits of nintedanib in lung adenocarcinoma.
Duch P, Díaz-Valdivia N, Gabasa M, Ikemori R, Arshakyan M, Fernández-Nogueira P, Llorente A, Teixido C, Ramírez J, Pereda J, Chuliá-Peris L, Galbis JM, Hilberg F, Reguart N, Radisky DC, Alcaraz J. Duch P, et al. Among authors: hilberg f. Cancer Sci. 2024 Mar 12. doi: 10.1111/cas.16141. Online ahead of print. Cancer Sci. 2024. PMID: 38476010 Free article.
Pharmacodynamic and Antitumor Activity of BI 836880, a Dual Vascular Endothelial Growth Factor and Angiopoietin 2 Inhibitor, Alone and Combined with Programmed Cell Death Protein-1 Inhibition.
Hofmann I, Baum A, Hofmann MH, Trapani F, Reichel-Voda C, Ehrensperger D, Aichinger M, Ebner F, Budano N, Schweifer N, Sykora M, Depla E, Boucneau J, Gschwind A, Kraut N, Hilberg F, Künkele KP. Hofmann I, et al. Among authors: hilberg f. J Pharmacol Exp Ther. 2023 Mar;384(3):331-342. doi: 10.1124/jpet.122.001255. Epub 2022 Oct 14. J Pharmacol Exp Ther. 2023. PMID: 36241203
Nintedanib targets KIT D816V neoplastic cells derived from induced pluripotent stem cells of systemic mastocytosis.
Toledo MAS, Gatz M, Sontag S, Gleixner KV, Eisenwort G, Feldberg K, Hamouda AEI, Kluge F, Guareschi R, Rossetti G, Sechi AS, Dufva OMJ, Mustjoki SM, Maurer A, Schüler HM, Goetzke R, Braunschweig T, Kaiser A, Panse J, Jawhar M, Reiter A, Hilberg F, Ettmayer P, Wagner W, Koschmieder S, Brümmendorf TH, Valent P, Chatain N, Zenke M. Toledo MAS, et al. Among authors: hilberg f. Blood. 2021 Apr 15;137(15):2070-2084. doi: 10.1182/blood.2019004509. Blood. 2021. PMID: 33512435 Free article.
Selective Tumor Cell Apoptosis and Tumor Regression in CDH17-Positive Colorectal Cancer Models using BI 905711, a Novel Liver-Sparing TRAILR2 Agonist.
García-Martínez JM, Wang S, Weishaeupl C, Wernitznig A, Chetta P, Pinto C, Ho J, Dutcher D, Gorman PN, Kroe-Barrett R, Rinnenthal J, Giragossian C, Impagnatiello MA, Tirapu I, Hilberg F, Kraut N, Pearson M, Kuenkele KP. García-Martínez JM, et al. Among authors: hilberg f. Mol Cancer Ther. 2021 Jan;20(1):96-108. doi: 10.1158/1535-7163.MCT-20-0253. Epub 2020 Oct 9. Mol Cancer Ther. 2021. PMID: 33037135
Nintedanib and a bi-specific anti-VEGF/Ang2 nanobody selectively prevent brain metastases of lung adenocarcinoma cells.
Kovalchuk B, Berghoff AS, Karreman MA, Frey K, Piechutta M, Fischer M, Grosch J, Heiland S, Breckwoldt MO, Hilberg F, Wick W, Winkler F. Kovalchuk B, et al. Among authors: hilberg f. Clin Exp Metastasis. 2020 Dec;37(6):637-648. doi: 10.1007/s10585-020-10055-x. Epub 2020 Sep 12. Clin Exp Metastasis. 2020. PMID: 32918638 Free PMC article.
Epigenetic SMAD3 Repression in Tumor-Associated Fibroblasts Impairs Fibrosis and Response to the Antifibrotic Drug Nintedanib in Lung Squamous Cell Carcinoma.
Ikemori R, Gabasa M, Duch P, Vizoso M, Bragado P, Arshakyan M, Luis IC, Marín A, Morán S, Castro M, Fuster G, Gea-Sorli S, Jauset T, Soucek L, Montuenga LM, Esteller M, Monsó E, Peinado VI, Gascon P, Fillat C, Hilberg F, Reguart N, Alcaraz J. Ikemori R, et al. Among authors: hilberg f. Cancer Res. 2020 Jan 15;80(2):276-290. doi: 10.1158/0008-5472.CAN-19-0637. Epub 2019 Nov 6. Cancer Res. 2020. PMID: 31694906
46 results