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Nintedanib targets KIT D816V neoplastic cells derived from induced pluripotent stem cells of systemic mastocytosis.
Toledo MAS, Gatz M, Sontag S, Gleixner KV, Eisenwort G, Feldberg K, Hamouda AEI, Kluge F, Guareschi R, Rossetti G, Sechi AS, Dufva OMJ, Mustjoki SM, Maurer A, Schüler HM, Goetzke R, Braunschweig T, Kaiser A, Panse J, Jawhar M, Reiter A, Hilberg F, Ettmayer P, Wagner W, Koschmieder S, Brümmendorf TH, Valent P, Chatain N, Zenke M. Toledo MAS, et al. Among authors: hilberg f. Blood. 2021 Apr 15;137(15):2070-2084. doi: 10.1182/blood.2019004509. Blood. 2021. PMID: 33512435 Free article.
Targeting receptor kinases by a novel indolinone derivative in multiple myeloma: abrogation of stroma-derived interleukin-6 secretion and induction of apoptosis in cytogenetically defined subgroups.
Bisping G, Kropff M, Wenning D, Dreyer B, Bessonov S, Hilberg F, Roth GJ, Munzert G, Stefanic M, Stelljes M, Scheffold C, Müller-Tidow C, Liebisch P, Lang N, Tchinda J, Serve HL, Mesters RM, Berdel WE, Kienast J. Bisping G, et al. Among authors: hilberg f. Blood. 2006 Mar 1;107(5):2079-89. doi: 10.1182/blood-2004-11-4250. Epub 2005 Nov 8. Blood. 2006. PMID: 16278310 Free article.
Drug resistance profiles of mutations in the RET kinase domain.
Liu X, Shen T, Mooers BHM, Hilberg F, Wu J. Liu X, et al. Among authors: hilberg f. Br J Pharmacol. 2018 Sep;175(17):3504-3515. doi: 10.1111/bph.14395. Epub 2018 Jul 19. Br J Pharmacol. 2018. PMID: 29908090 Free PMC article.
Nintedanib: from discovery to the clinic.
Roth GJ, Binder R, Colbatzky F, Dallinger C, Schlenker-Herceg R, Hilberg F, Wollin SL, Kaiser R. Roth GJ, et al. Among authors: hilberg f. J Med Chem. 2015 Feb 12;58(3):1053-63. doi: 10.1021/jm501562a. Epub 2015 Jan 14. J Med Chem. 2015. PMID: 25474320 Review.
Nintedanib Is Active in Malignant Pleural Mesothelioma Cell Models and Inhibits Angiogenesis and Tumor Growth In Vivo.
Laszlo V, Valko Z, Kovacs I, Ozsvar J, Hoda MA, Klikovits T, Lakatos D, Czirok A, Garay T, Stiglbauer A, Helbich TH, Gröger M, Tovari J, Klepetko W, Pirker C, Grusch M, Berger W, Hilberg F, Hegedus B, Dome B. Laszlo V, et al. Among authors: hilberg f. Clin Cancer Res. 2018 Aug 1;24(15):3729-3740. doi: 10.1158/1078-0432.CCR-17-1507. Epub 2018 May 3. Clin Cancer Res. 2018. PMID: 29724868
Nintedanib and a bi-specific anti-VEGF/Ang2 nanobody selectively prevent brain metastases of lung adenocarcinoma cells.
Kovalchuk B, Berghoff AS, Karreman MA, Frey K, Piechutta M, Fischer M, Grosch J, Heiland S, Breckwoldt MO, Hilberg F, Wick W, Winkler F. Kovalchuk B, et al. Among authors: hilberg f. Clin Exp Metastasis. 2020 Dec;37(6):637-648. doi: 10.1007/s10585-020-10055-x. Epub 2020 Sep 12. Clin Exp Metastasis. 2020. PMID: 32918638 Free PMC article.
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