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Discovery of DS-9300: A Highly Potent, Selective, and Once-Daily Oral EP300/CBP Histone Acetyltransferase Inhibitor.
Kanada R, Kagoshima Y, Suzuki T, Nakamura A, Funami H, Watanabe J, Asano M, Takahashi M, Ubukata O, Suzuki K, Aikawa T, Sato K, Goto M, Setsu G, Ito K, Kihara K, Kuroha M, Kohno T, Ogiwara H, Isoyama T, Tominaga Y, Higuchi S, Naito H. Kanada R, et al. Among authors: higuchi s. J Med Chem. 2023 Jan 12;66(1):695-715. doi: 10.1021/acs.jmedchem.2c01641. Epub 2022 Dec 26. J Med Chem. 2023. PMID: 36572866
Discovery of EP300/CBP histone acetyltransferase inhibitors through scaffold hopping of 1,4-oxazepane ring.
Kanada R, Kagoshima Y, Asano M, Suzuki T, Murata T, Haruta M, Takahashi M, Ubukata O, Hashimoto K, Obata K, Kihara K, Kuroha M, Banjo T, Togashi N, Sato K, Yamamoto Y, Suzuki K, Isoyama T, Tominaga Y, Higuchi S, Naito H. Kanada R, et al. Among authors: higuchi s. Bioorg Med Chem Lett. 2022 Jun 15;66:128726. doi: 10.1016/j.bmcl.2022.128726. Epub 2022 Apr 9. Bioorg Med Chem Lett. 2022. PMID: 35413416
Highly potent, orally active novel small-molecule HPK1 inhibitor DS21150768 induces anti-tumor responses in multiple syngeneic tumor mouse models.
Setsu G, Goto M, Ito K, Taira T, Miyamoto M, Watanabe T, Taniguchi T, Umezaki Y, Nakazawa Y, Uesugi S, Mori K, Horiuchi T, Obuchi W, Minami M, Shimada T, Wada C, Yoshida T, Higuchi S. Setsu G, et al. Among authors: higuchi s. Eur J Pharmacol. 2023 Dec 15;961:176184. doi: 10.1016/j.ejphar.2023.176184. Epub 2023 Nov 8. Eur J Pharmacol. 2023. PMID: 37944847
In vitro and in vivo antibacterial activities of DC-159a, a new fluoroquinolone.
Hoshino K, Inoue K, Murakami Y, Kurosaka Y, Namba K, Kashimoto Y, Uoyama S, Okumura R, Higuchi S, Otani T. Hoshino K, et al. Among authors: higuchi s. Antimicrob Agents Chemother. 2008 Jan;52(1):65-76. doi: 10.1128/AAC.00853-07. Epub 2007 Oct 15. Antimicrob Agents Chemother. 2008. PMID: 17938194 Free PMC article.
1,438 results