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Review: Microglia in motor neuron disease.
Ashford BA, Boche D, Cooper-Knock J, Heath PR, Simpson JE, Highley JR. Ashford BA, et al. Among authors: highley jr. Neuropathol Appl Neurobiol. 2021 Feb;47(2):179-197. doi: 10.1111/nan.12640. Epub 2020 Jul 21. Neuropathol Appl Neurobiol. 2021. PMID: 32594542 Free article. Review.
Gene expression signatures in motor neurone disease fibroblasts reveal dysregulation of metabolism, hypoxia-response and RNA processing functions.
Raman R, Allen SP, Goodall EF, Kramer S, Ponger LL, Heath PR, Milo M, Hollinger HC, Walsh T, Highley JR, Olpin S, McDermott CJ, Shaw PJ, Kirby J. Raman R, et al. Among authors: highley jr. Neuropathol Appl Neurobiol. 2015 Feb;41(2):201-26. doi: 10.1111/nan.12147. Neuropathol Appl Neurobiol. 2015. PMID: 24750211 Free PMC article.
Loss of nuclear TDP-43 in amyotrophic lateral sclerosis (ALS) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurones.
Highley JR, Kirby J, Jansweijer JA, Webb PS, Hewamadduma CA, Heath PR, Higginbottom A, Raman R, Ferraiuolo L, Cooper-Knock J, McDermott CJ, Wharton SB, Shaw PJ, Ince PG. Highley JR, et al. Neuropathol Appl Neurobiol. 2014 Oct;40(6):670-85. doi: 10.1111/nan.12148. Neuropathol Appl Neurobiol. 2014. PMID: 24750229
Bioenergetic status modulates motor neuron vulnerability and pathogenesis in a zebrafish model of spinal muscular atrophy.
Boyd PJ, Tu WY, Shorrock HK, Groen EJN, Carter RN, Powis RA, Thomson SR, Thomson D, Graham LC, Motyl AAL, Wishart TM, Highley JR, Morton NM, Becker T, Becker CG, Heath PR, Gillingwater TH. Boyd PJ, et al. Among authors: highley jr. PLoS Genet. 2017 Apr 20;13(4):e1006744. doi: 10.1371/journal.pgen.1006744. eCollection 2017 Apr. PLoS Genet. 2017. PMID: 28426667 Free PMC article.
A data-driven approach links microglia to pathology and prognosis in amyotrophic lateral sclerosis.
Cooper-Knock J, Green C, Altschuler G, Wei W, Bury JJ, Heath PR, Wyles M, Gelsthorpe C, Highley JR, Lorente-Pons A, Beck T, Doyle K, Otero K, Traynor B, Kirby J, Shaw PJ, Hide W. Cooper-Knock J, et al. Among authors: highley jr. Acta Neuropathol Commun. 2017 Mar 16;5(1):23. doi: 10.1186/s40478-017-0424-x. Acta Neuropathol Commun. 2017. PMID: 28302159 Free PMC article.
TIGAR inclusion pathology is specific for Lewy body diseases.
López KLR, Simpson JE, Watson LC, Mortiboys H, Hautbergue GM, Bandmann O, Highley JR. López KLR, et al. Among authors: highley jr. Brain Res. 2019 Mar 1;1706:218-223. doi: 10.1016/j.brainres.2018.09.032. Epub 2018 Sep 26. Brain Res. 2019. PMID: 30267647 Free article.
Brain haemosiderin in older people: pathological evidence for an ischaemic origin of magnetic resonance imaging (MRI) microbleeds.
Janaway BM, Simpson JE, Hoggard N, Highley JR, Forster G, Drew D, Gebril OH, Matthews FE, Brayne C, Wharton SB, Ince PG; MRC Cognitive Function and Ageing Neuropathology Study. Janaway BM, et al. Among authors: highley jr. Neuropathol Appl Neurobiol. 2014 Apr;40(3):258-69. doi: 10.1111/nan.12062. Neuropathol Appl Neurobiol. 2014. PMID: 23678850 Free PMC article.
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